ArticleCurrent opinion in behavioral sciences2018
Impact of sex on pain and opioid analgesia: a review.
Article in Current opinion in behavioral sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Sex differences in the response to opioids for pain relief: A systematic review and meta-analysis.Pharmacological research · 2019Pooled it
- Sex Differences in the Effects of L-Menthol on Nociception in the Hot Plate Test and Acetic Acid Writhing Test in BALB/c Mice.Iranian journal of medical sciences · 2026Article
- Acute buprenorphine exposure depresses neonatal respiratory chemoreflexes in the presence or absence of naloxone.bioRxiv : the preprint server for biology · 2026Article
- Comparison of Opioid Utilization in Older Adults with Rheumatoid Arthritis before and after Initiating Biological or Targeted Synthetic Disease-Modifying Antirheumatic Drugs.Drugs - real world outcomes · 2026Article
- Sex-Related Differences in Chronic Pain: A Narrative Review by a Multidisciplinary Task Force.Medicina (Kaunas, Lithuania) · 2025Review
- A review of the effects of different types of social behaviors on the recruitment of neuropeptides and neurotransmitters in the nucleus accumbens.Frontiers in neuroendocrinology · 2025Review
- Does heightened subjective sexual arousal lower pain in women if disgust is minimized?PloS one · 2025Article
- The role of gonadal hormones in regulating opioid antinociception.Annals of medicine · 2024Review
- Behavioral and neural correlates of diverse conditioned fear responses in male and female rats.Neurobiology of stress · 2024Article
- Behavioral and neural correlates of diverse conditioned fear responses in male and female rats.bioRxiv : the preprint server for biology · 2024Article
- Sex differences in opioid response: a role for the gut microbiome?Frontiers in pharmacology · 2024Review
- Morphine-context associative memory and locomotor sensitization in mice are modulated by sex and context in a dose-dependent manner.bioRxiv : the preprint server for biology · 2023Article
- Persistent inflammation selectively activates opioid-sensitive phasic-firing neurons within the vlPAG.Journal of neurophysiology · 2023Article
- Molecular identification of bulbospinal ON neurons by GPER, which drives pain and morphine tolerance.The Journal of clinical investigation · 2023Article
- Article
- Kratom alkaloid mitragynine: Inhibition of chemotherapy-induced peripheral neuropathy in mice is dependent on sex and active adrenergic and opioid receptors.IBRO neuroscience reports · 2022Article
- Opioid use for a first-incident upper extremity fracture in 220,440 patients without recent prior use in Ontario, Canada: a retrospective cohort study.OTA international : the open access journal of orthopaedic trauma · 2022Article
- Impact of individual and treatment characteristics on wearable sensor-based digital biomarkers of opioid use.NPJ digital medicine · 2022Article
- Darting across space and time: parametric modulators of sex-biased conditioned fear responses.Learning & memory (Cold Spring Harbor, N.Y.) · 2022Article
- Identification of sex-specific genetic associations in response to opioid analgesics in a White, non-Hispanic cohort from Southeast Minnesota.The pharmacogenomics journal · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Chronic pain is a debilitating condition that impacts tens of millions each year, resulting in lost wages for workers and exacting considerable costs in health care and rehabilitation. A thorough understanding of the neural mechanisms underlying pain and analgesia is critical to facilitate the development of therapeutic strategies and personalized medicine. Clinical and epidemiological studies report that women experience greater levels of pain than men and have higher rates of pain-related disorders. Studies in both rodents and humans report sex differences in the anatomical and physiologic properties of the descending antinociceptive circuit, mu opioid receptor (MOR) expression and binding, morphine metabolism, and immune system activation, all of which likely contribute to the observed sex differences in pain and opioid analgesia. Although more research is needed to elucidate the underlying mechanisms, these sex differences present potential therapeutic targets to optimize pain management strategies for both sexes.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.