Evidence map›Paper›PMID 30906789›Full record

ArticleJournal of immunology research2019

Evaluation of EBV- and HCMV-Specific T Cell Responses in Systemic Lupus Erythematosus (SLE) Patients Using a Normalized Enzyme-Linked Immunospot (ELISPOT) Assay.

Irene Cassaniti, Lorenzo Cavagna, Sandra A Calarota, Kodjo Messan Guy Adzasehoun, Giuditta Comolli, Carlomaurizio Montecucco, Fausto Baldanti

Abstract read
In one paragraph

Article in Journal of immunology research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Irene CassanitiMolecular Virology Unit, Microbiology and Virology Department, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Lorenzo CavagnaRheumatology Department, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.ORCID 0000-0003-3292-1528
Sandra A CalarotaMolecular Virology Unit, Microbiology and Virology Department, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.ORCID 0000-0002-3668-6441
Kodjo Messan Guy AdzasehounMolecular Virology Unit, Microbiology and Virology Department, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Giuditta ComolliMolecular Virology Unit, Microbiology and Virology Department, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Carlomaurizio MontecuccoRheumatology Department, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Fausto BaldantiMolecular Virology Unit, Microbiology and Virology Department, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.ORCID 0000-0002-5178-7996

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease with a complex etiology. Opportunistic viral pathogens, such as human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV), are particularly relevant. The role of the T cell response in SLE has not been deeply studied; we investigated the role of HCMV- and EBV-specific T cell responses in SLE patients also in relation to their pharmacological immunosuppressive status. PBMCs from 70 SLE patients and 50 healthy controls were stimulated with EBV- and HCMV-specific antigens, and IFN-

Indexed as

AdultAntigens, ViralCD8-Positive T-LymphocytesCells, CulturedCytomegalovirusCytomegalovirus InfectionsEnzyme-Linked Immunospot AssayEpstein-Barr Virus InfectionsFemaleHerpesvirus 4, HumanHumansInterferon-gammaLupus Erythematosus, SystemicLymphocyte ActivationMaleMiddle AgedAntigens, ViralInterferon-gamma

Identifiers

PMID30906789
PMCPMC6397965

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.