Evidence map›Paper›PMID 30906737›Full record

ArticleFrontiers in bioengineering and biotechnology2019

Drug Delivery From Polymer-Based Nanopharmaceuticals-An Experimental Study Complemented by Simulations of Selected Diffusion Processes.

Innocent J Macha, Besim Ben-Nissan, Elena N Vilchevskaya, Anna S Morozova, Bilen Emek Abali, Wolfgang H Müller, W Rickert

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 73 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Innocent J MachaDepartment of Mechanical and Industrial Engineering, University of Dar es Salaam, Dar es Salaam, Tanzania.
Besim Ben-NissanFaculty of Science, School of Life Sciences, University of Technology Sydney, Sydney, NSW, Australia.
Elena N VilchevskayaApplied Research Laboratory, Department of Theoretical Mechanics, Institute for Problems in Mechanical Engineering of the Russian Academy of Sciences and Peter the Great St. Petersburg Polytechnic University, St. Petersburg, Russia.
Anna S MorozovaApplied Research Laboratory, Department of Theoretical Mechanics, Institute for Problems in Mechanical Engineering of the Russian Academy of Sciences and Peter the Great St. Petersburg Polytechnic University, St. Petersburg, Russia.
Bilen Emek AbaliInstitute of Mechanics, Faculty V of Mechanical Engineering and Transport Systems, Berlin University of Technology, LKM, Berlin, Germany.
Wolfgang H MüllerInstitute of Mechanics, Faculty V of Mechanical Engineering and Transport Systems, Berlin University of Technology, LKM, Berlin, Germany.
W RickertInstitute of Mechanics, Faculty V of Mechanical Engineering and Transport Systems, Berlin University of Technology, LKM, Berlin, Germany.
Russian Academy of Sciences · RUUniversity of Dar es Salaam · TZUniversity of Technology Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The success of medical therapy depends on the correct amount and the appropriate delivery of the required drugs for treatment. By using biodegradable polymers a drug delivery over a time span of weeks or even months is made possible. This opens up a variety of strategies for better medication. The drug is embedded in a biodegradable polymer (the "carrier") and injected in a particular position of the human body. As a consequence of the interplay between the diffusion process and the degrading polymer the drug is released in a controlled manner. In this work we study the controlled release of medication experimentally by measuring the delivered amount of drug within a cylindrical shell over a long time interval into the body fluid. Moreover, a simple continuum model of the Fickean type is initially proposed and solved in closed-form. It is used for simulating some of the observed release processes for this type of carrier and takes the geometry of the drug container explicitly into account. By comparing the measurement data and the model predictions diffusion coefficients are obtained. It turns out that within this simple model the coefficients change over time. This contradicts the idea that diffusion coefficients are constants independent of the considered geometry. The model is therefore extended by taking an additional absorption term into account leading to a concentration dependent diffusion coefficient. This could now be used for further predictions of drug release in carriers of different shape. For a better understanding of the complex diffusion and degradation phenomena the underlying physics is discussed in detail and even more sophisticated models involving different degradation and mass transport phenomena are proposed for future work and study.

Indexed as

biphosphonatediffusion coefficientgentamicinmodelingpolylacetic acid

Identifiers

PMID30906737
PMCPMC6418005
OpenAlexW2921594146

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.