Evidence map›Paper›PMID 30906674›Full record

ArticleJournal of liver2018

Quantification of Hepatic Lipid Using 7.0T Proton Magnetic Resonance Spectroscopy and Computed Tomography in Mild Alcoholic Steatotic Mice.

Qi Cao, Su Xu, Shujing Li, Minjie Chen, Xicui Sun, Yamin Wan, Liya Pi, Zhekang Ying, Bin Ren

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of liver, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Qi CaoDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Su XuDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Shujing LiDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Minjie ChenDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Xicui SunDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Yamin WanDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Liya PiDepartment of Pediatrics in the College of Medicine, University of Florida, Gainesville, Florida, USA.
Zhekang YingDepartment of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Bin RenDepartment of Surgery, University of Alabama at Birmingham School of Medicine, Alabama, USA.
University of Maryland, Baltimore · USFirst Affiliated Hospital of Zhengzhou University · CNHebei Medical University · CNUniversity of Alabama at Birmingham · USUniversity of Florida · US

Funding

Epigenetic and Transcriptional Regulation of Angiogenic Regulator CD36 and Transformation of Capillaries into Small ArteriesR01HL136423 · NHLBI · VERSITI WISCONSIN, INC. · PI REN, BIN · 2017 to 2020
$1.6M
18F Proline Preclinical PET Imaging In The Diagnosis of Early Stage Alcoholic Liver FibrosisK08AA024895 · NIAAA · UNIVERSITY OF MARYLAND BALTIMORE · PI CAO, QI · 2017 to 2021
$953k
NHLBI NIH HHS R01 HL136423NIAAA NIH HHS K08 AA024895
6 · The paper itself

Abstract

backgroundIn vivo proton magnetic resonance spectroscopy ( PURPOSE: To establish reliable parameters to convert relative hepatic lipid levels obtained by 1H-MRS and liver volumes by CT to the absolute amount of liver lipids in a mild hepatic steatosis, and to determinate the correlation between these absolute liver lipids with liver triglyceride (TG) and cholesterol (Chol) measured by biochemistry assays.

methodsMild steatosis was induced in mice by a 3 week ethanol diet containing standard lipids. Evaporated liver water was measured after baking liver tissues and volume of liver was measured using water displacement. 1H MRS semiquantitation of hepatic lipids and CT measurement of liver volume were performed and then used to calculate amount of liver lipids. These data were compared with liver TG and Chol.

resultsPercentage of liver water and liver density were persistent in two groups and were used to convert the percentage of liver lipids to liver water by 1H-MRS to the absolute amount of liver lipids per gram of liver or per milliliter of CT volume. Using 1H-MRS and biochemical assays, an increase of liver lipids was confirmed in mild steatosis mice compared to controls (P<0.01). The amounts of imaging detected liver lipids were strongly correlated to liver TG and Chol measured by biochemical assays in mild steatosis mice.

conclusion1H MRS and CT liver imaging techniques are able to quantify absolute hepatic lipid levels utilizing relative persistent parameters percentage of liver water and liver density in a preclinical mild steatosis setting.

Indexed as

Alcoholic hepatic steatosisCholesterolComputed tomographyLiver densityPercentage of liver waterProton magnetic resonance spectroscopyTriglyceride

Identifiers

PMID30906674
PMCPMC6428077
OpenAlexW2908588207

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.