Evidence map›Paper›PMID 30906661›Full record

ArticleOncoimmunology

Anti-tumor immunity induced by ectopic expression of viral antigens is transient and limited by immune escape.

Neeraja Dharmaraj, Stacey L Piotrowski, Chen Huang, Jared M Newton, Leonard S Golfman, Aurelie Hanoteau, Sandeep T Koshy, Aileen W Li, Merlyn X Pulikkathara, Bing Zhang and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncoimmunology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 32 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 1 country.

Neeraja DharmarajDepartment of Oral & Maxillofacial Surgery, University of Texas Health Science Center at Houston, School of Dentistry, Houston, TX, USA.
Stacey L PiotrowskiDepartment of Oral & Maxillofacial Surgery, University of Texas Health Science Center at Houston, School of Dentistry, Houston, TX, USA.
Chen HuangLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA.
Jared M NewtonDepartment of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, TX, USA.
Leonard S GolfmanDepartment of Oral & Maxillofacial Surgery, University of Texas Health Science Center at Houston, School of Dentistry, Houston, TX, USA.
Aurelie HanoteauDepartment of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, TX, USA.
Sandeep T KoshyJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.
Aileen W LiJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.
Merlyn X PulikkatharaDepartment of Surgery, Baylor College of Medicine, Houston, TX, USA.
Bing ZhangLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA.
Jared K BurksDepartment of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
David J MooneyJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.
Yu L LeiDepartment of Periodontics and Oral Medicine, University of Michigan Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI, USA.
Andrew G SikoraDepartment of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, TX, USA.
Simon YoungDepartment of Oral & Maxillofacial Surgery, University of Texas Health Science Center at Houston, School of Dentistry, Houston, TX, USA.ORCID 0000-0002-8198-7083
Baylor College of Medicine · USHarvard University · USThe University of Texas Health Science Center at Houston · USPurdue University West Lafayette · USThe University of Texas MD Anderson Cancer Center · USUniversity of Michigan · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
Training Program in Translational Biology and Molecular MedicineT32GM088129 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI ROONEY, CLIONA M., VAN DEN VEYVER, IGNATIA B · 2010 to 2019
$3.0M
The Use of Novel Implantable Cancer Vaccines for the Treatment of Oral CancerR00DE023577 · NIDCR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI YOUNG, SIMON · 2015 to 2017
$747k
Immunomodulatory Nanoparticles in Combination with Immune Checkpoint Inhibitors for the Systemic Treatment of Immunosuppressive HPV Associated Oropharyngeal CancerF31DE026682 · NIDCR · BAYLOR COLLEGE OF MEDICINE · PI NEWTON, JARED MICHAEL · 2016 to 2019
$118k
NCI NIH HHS P30 CA016672NIDCR NIH HHS F31 DE026682NIDCR NIH HHS R00 DE023577NIGMS NIH HHS T32 GM088129
6 · The paper itself

Abstract

Immunotherapeutic treatments in head and neck cancer clinical trials include cancer vaccines targeting foreign viral antigens or mutational neoantigens derived from cancer-expressed proteins. Anti-tumor immune responses place cancer cells under selective pressure to lose or downregulate target antigens; therefore, vaccination against virus- or host- "driver" oncogenes are proposed as a strategy to overcome immune escape. Herein, we demonstrate the impact of immunogenic viral antigens on anti-tumor response and immune editing in MOC2-E6E7, a syngeneic murine oral cancer cell line expressing HPV-16 E6 and E7 oncoproteins. Using orthotopic syngeneic models, we observed

Indexed as

biomaterialscancer vaccinehead and neck cancerHPV16 E6 and E7Immune editingimmunotherapymesoporous silica rods

Identifiers

PMID30906661
PMCPMC6422387
OpenAlexW2914084076

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.