ArticleAmerican journal of cancer research2019
A sex-dimorphic mouse model of esophageal squamous cell carcinoma.
Article in American journal of cancer research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed, 4 citations in OpenAlex.
- A method for scoring 4-nitroquinoline 1-oxide-induced murine esophageal squamous neoplasia.Veterinary pathology · 2023Article
- Potential Chemotherapeutic Effect of Selenium for Improved Canceration of Esophageal Cancer.International journal of molecular sciences · 2022Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sexual dimorphism in the incidence of human esophageal cancer, including both esophageal adenocarcinoma and squamous cell carcinoma, shows male dominancy. However, the mechanisms that underlie sexual dimorphism of esophageal cancer have been understudied in vivo due to the lack of sex-dimorphic mouse models. Here, we developed a sex-dimorphic mouse model of esophageal squamous cell carcinoma (ESCC) using a lower amount of 4-nitroquinoline-1-oxide (4-NQO) and a shorter latency of tumorigenesis compared to the traditional carcinogenesis procedures. In this model, we found that male mice were highly sensitive to the tumorigenesis of ESCC whereas female mice were resistant to it. This model provided us an opportunity for investigating the mechanisms underlying sexual dimorphism of ESCC in vivo and for better understanding the sex-dimorphic incidence of ESCC in humans.
Indexed as
Identifiers
30906640PMC6405973W2984588025What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.