Genetic ablation of mammary ducts through foxa1 prevents breast cancer occurrence.

Daoshan Zheng, Sarah A McLaughlin, Klaus H Kaestner, Zhaoyu Li

Open access · greenAbstract read

In one paragraph

Article in American journal of cancer research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.4field-weighted citation impact, top 29% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

Deletion ofAmerican journal of cancer research · 2021
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Daoshan ZhengDepartment of Cancer Biology, Mayo Clinic 4500 San Pablo Road, Jacksonville, FL 32224, USA.

Sarah A McLaughlinDepartment of Surgery, Mayo Clinic 4500 San Pablo Road, Jacksonville, FL 32224, USA.

Klaus H KaestnerDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania Philadelphia, PA 19104, USA.

Zhaoyu LiDepartment of Cancer Biology, Mayo Clinic 4500 San Pablo Road, Jacksonville, FL 32224, USA.

Mayo Clinic in Florida · USUniversity of Pennsylvania · US

Funding

Comparative Genomics Study of Foxa/ER Targets in Liver Cancer and Breast CancerR00CA168983 · NCI · MAYO CLINIC JACKSONVILLE · PI LI, ZHAOYU · 2013 to 2015

$725k

NCI NIH HHS R00 CA168983

6 · The paper itself

Abstract

Risk reducing mastectomy is the only surgical approach for the prevention of breast cancer in women with deleterious genetic mutations or in those deemed to be at extremely high risk. However, up to 10.5% of these women still developed breast cancer. Thus, developing new strategies for complete prevention of breast cancer is imperative. Mammary ducts were ablated by mammary-specific ablation of forkhead box protein A1 (Foxa1). Mammary tumorigenesis was induced in control and mammary-specific Foxa1 knockout mice using carcinogens. No mammary tumors were observed in these knockout mice compared to four types of breast tumors induced in control mice. We present a promising novel strategy for the prevention of breast cancer by genetic ablation of mammary ducts via targeting Foxa1.

Indexed as

breast cancer preventioncarcinogenesisFoxa1mammary ductsmastectomy

Identifiers

PMID30906639

PMCPMC6405962

OpenAlexW2984531367

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.