Evidence map›Paper›PMID 30906636›Full record

ArticleAmerican journal of cancer research2019

Inhibition of invasive pancreatic cancer: restoring cell apoptosis by activating mitochondrial p53.

Jiongjia Cheng, Karl J Okolotowicz, Daniel Ryan, Evangeline Mose, Andrew M Lowy, John R Cashman

Open access · greenAbstract read
In one paragraph

Article in American journal of cancer research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jiongjia ChengHuman BioMolecular Research Institute and ChemRegen, Inc. San Diego, CA 92121, USA.
Karl J OkolotowiczHuman BioMolecular Research Institute and ChemRegen, Inc. San Diego, CA 92121, USA.
Daniel RyanHuman BioMolecular Research Institute and ChemRegen, Inc. San Diego, CA 92121, USA.
Evangeline MoseDepartment of Surgery, Division of Surgical Oncology, University of California at San Diego, Moores Cancer Center La Jolla, CA 92093, USA.
Andrew M LowyDepartment of Surgery, Division of Surgical Oncology, University of California at San Diego, Moores Cancer Center La Jolla, CA 92093, USA.
John R CashmanHuman BioMolecular Research Institute and ChemRegen, Inc. San Diego, CA 92121, USA.
Human BioMolecular Research Institute · USUniversity of California San Diego · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pancreatic ductal adenocarcinoma (PDAC), constitutes >90% of pancreatic cancers (PC) and is one of the most aggressive human tumors. Standard chemotherapies for PDAC (e.g., gemcitabine, FOLFIRINOX, etc.) has proven to be largely ineffective. Herein, we report a novel molecule (i.e., compound

Indexed as

DNA damage pathwaymitochondrial control of apoptosisorthotopic syngeneic modelp53 activationPancreatic cancerpancreatic ductal adenocarcinoma (PDAC)

Identifiers

PMID30906636
PMCPMC6405982
OpenAlexW2988016252

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.