Evidence map›Paper›PMID 30906561›Full record

ArticlePharmacology research & perspectives2019

Nicotine oxidation by genetic variants of CYP2B6 and in human brain microsomes.

Adam Joseph Bloom, Pan-Fen Wang, Evan D Kharasch

Open access · goldAbstract read
In one paragraph

Article in Pharmacology research & perspectives, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

  1. Achieving a Deeper Understanding of Drug Metabolism and Responses Using Single-Cell Technologies.Drug metabolism and disposition: the biological fate of chemicals · 2023
    Review
  2. Article
  3. CYP2C19 Plays a Major Role in the HepaticDrug metabolism and disposition: the biological fate of chemicals · 2023
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Impact of Nicotine Replacement and Electronic Nicotine Delivery Systems on Fetal Brain Development.International journal of environmental research and public health · 2019
    Review
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Adam Joseph BloomDepartment of Psychiatry and Anesthesiology Washington University St. Louis Missouri.
Pan-Fen WangDepartment of Anesthesiology Duke University School of Medicine Durham North Carolina.
Evan D KharaschDepartment of Anesthesiology Duke University School of Medicine Durham North Carolina.
Duke University · USWashington University in St. Louis · US

Funding

Research Resource for Human Organs and Tissues (U42)U42OD011158 · OD · NATIONAL DISEASE RESEARCH INTERCHANGE · PI BELL, THOMAS J · 2012 to 2025
$25.0M
ADDICTION THERAPY: METABOLISM AND TRANSPORT-MEDIATED DRUG INTERACTIONSR01DA025931 · NIDA · WASHINGTON UNIVERSITY · PI KHARASCH, EVAN D. · 2008 to 2012
$1.7M
NOVEL APPROACHES TO INVESTIGATE GENETIC CORRELATES OF SMOKING BEHAVIORSK01DA034035 · NIDA · WASHINGTON UNIVERSITY · PI BLOOM, ADAM JOSEPH · 2014 to 2018
$706k
NIDA NIH HHS K01 DA034035NIDA NIH HHS R01 DA025931NIH HHS U42 OD011158
6 · The paper itself

Abstract

Common variation in the

Indexed as

Polymorphism, Single NucleotideAgedAged, 80 and overBrainCytochrome P-450 CYP2B6FemaleHumansKetamineMaleMethadoneMicrosomesMiddle AgedNicotineOxidation-ReductionRecombinant ProteinsStereoisomerismCYP2B6 protein, humanCytochrome P-450 CYP2B6KetamineMethadoneNicotinenicotine iminenornicotineRecombinant ProteinsbrainCYP2B6microsomesnicotine

Identifiers

PMID30906561
PMCPMC6411694
OpenAlexW2921565839

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.