Evidence map›Paper›PMID 30906556›Full record

ArticleJournal of materials chemistry. B2018

Enhancing anti-thrombogenicity of biodegradable polyurethanes through drug molecule incorporation.

Cancan Xu, Aneetta E Kuriakose, Danh Truong, Primana Punnakitikashem, Kytai T Nguyen, Yi Hong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of materials chemistry. B, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Cancan XuDepartment of Bioengineering, University of Texas at Arlington, Arlington, TX 76019, USA.
Aneetta E KuriakoseDepartment of Bioengineering, University of Texas at Arlington, Arlington, TX 76019, USA.
Danh TruongDepartment of Bioengineering, University of Texas at Arlington, Arlington, TX 76019, USA.
Primana PunnakitikashemDepartment of Bioengineering, University of Texas at Arlington, Arlington, TX 76019, USA.
Kytai T NguyenDepartment of Bioengineering, University of Texas at Arlington, Arlington, TX 76019, USA.
Yi HongDepartment of Bioengineering, University of Texas at Arlington, Arlington, TX 76019, USA.
The University of Texas at Arlington · US

Funding

Novel Engineered Particle Platform for Endothelium RegenerationR01HL118498 · NHLBI · UNIVERSITY OF TEXAS ARLINGTON · PI NGUYEN, KYTAI TRUONG, YANG, JIAN · 2014 to 2017
$1.5M
Interdisciplinary Training in Nanotechnology for Cardiovascular and Lung Diseases in North TexasT32HL134613 · NHLBI · UNIVERSITY OF TEXAS ARLINGTON · PI NGUYEN, KYTAI TRUONG · 2017 to 2021
$1.1M
Elastic printable biomaterials for 3-D bioprinting of vascular conduitR21HD090680 · NICHD · NORTHEASTERN UNIVERSITY · PI DAI, GUOHAO · 2017 to 2018
$425k
NHLBI NIH HHS R01 HL118498NHLBI NIH HHS T32 HL134613NICHD NIH HHS R21 HD090680
6 · The paper itself

Abstract

Sufficient and sustained anti-thrombogenicity is essential for blood-contacting materials, because blood coagulation and thrombosis caused by platelet adhesion and activation on material surfaces may lead to functional failure and even fatal outcomes. Covalently conjugating antithrombogenic moieties into polymer, instead of surface modifying or blending, can maintain the anti-thrombogenicity of polymer at a high level over a time range. In this study, series of randomly crosslinked, elastic, biodegradable polyurethanes (PU-DPA) were synthesized through a one-pot and one-step method from polycaprolactone (PCL) diol, hexamethylene diisocyanate (HDI) and anti-thrombogenic drug, dipyridamole (DPA). The mechanical properties, hydrophilicity,

Indexed as

anti-thrombogenicitybiodegradable polyurethaneblood-contactingdipyridamole

Identifiers

PMID30906556
PMCPMC6424506
OpenAlexW2885228296

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.