Evidence map›Paper›PMID 30906476›Full record

ArticleExperimental and therapeutic medicine2019

Autologous bone marrow stem cell therapy for patients undergoing coronary artery bypass grafting: A meta-analysis of 14 randomized controlled trials.

Shanlian Wu, Liang Yao, Peijing Yan, Qiangwei Bao, Xin Dong, Xingguang Liu, Yan Zhu, Xin Su, Aqian Wang, Yichao Duan and 3 more

Abstract read
In one paragraph

Article in Experimental and therapeutic medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Shanlian WuDepartment of Pathology, School of Basic Medicine, Gansu University of Chinese Medicine, Lanzhou, Gansu 730000, P.R. China.
Liang YaoInstitute of Clinical Research and Evidence-Based Medicine, Gansu Provincial Hospital, Lanzhou, Gansu 730000, P.R. China.
Peijing YanInstitute of Clinical Research and Evidence-Based Medicine, Gansu Provincial Hospital, Lanzhou, Gansu 730000, P.R. China.
Qiangwei BaoDepartment of Pathology, School of Basic Medicine, Gansu University of Chinese Medicine, Lanzhou, Gansu 730000, P.R. China.
Xin DongDepartment of Ultrasound, The Third Hospital of Gansu Province, Lanzhou, Gansu 730020, P.R. China.
Xingguang LiuDepartment of Cardiac Surgery, Gansu Provincial Hospital, Lanzhou, Gansu 730000, P.R. China.
Yan ZhuDepartment of Cardiology, Gansu Provincial Hospital, Lanzhou, Gansu 730000, P.R. China.
Xin SuDepartment of Cardiology, Gansu Provincial Hospital, Lanzhou, Gansu 730000, P.R. China.
Aqian WangDepartment of Cardiology, Gansu Provincial Hospital, Lanzhou, Gansu 730000, P.R. China.
Yichao DuanDepartment of Cardiology, Gansu Provincial Hospital, Lanzhou, Gansu 730000, P.R. China.
Kehu YangInstitute of Clinical Research and Evidence-Based Medicine, Gansu Provincial Hospital, Lanzhou, Gansu 730000, P.R. China.
Min ZhangDepartment of Pathology, Gansu Provincial Hospital, Lanzhou, Gansu 730000, P.R. China.
Yunshan CaoDepartment of Cardiology, Gansu Provincial Hospital, Lanzhou, Gansu 730000, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autologous bone marrow stem cell (BMSC) therapy is a novel option for regenerative therapy in patients with ischemic heart disease. The aim of the present meta-analysis was to evaluate the effectiveness of BMSCs combined with coronary artery bypass grafting (CABG). The PubMed, Cochrane Library, EMBASE and Web of Science databases were searched from inception to November 22, 2017 for randomized controlled trials on BMSC therapy combined with CABG. Finally, 14 trials with a total of 596 participants were included. Data were analyzed using a random-effects model. Compared with the control group, the BMSC therapy group exhibited an improvement in the left ventricular (LV) ejection fraction from baseline to follow-up [mean difference (MD)=4.36%; 95% confidence interval (CI): 1.90-6.81%; P<0.01]. Analysis of the pooled results revealed non-significant differences in the LV end-diastolic volume (MD=-6.27 ml; 95% CI: -22.34 to 9.80 ml; P=0.44), LV end-diastolic volume index (MD=-15.11 ml/m

Indexed as

bone marrowcoronary artery bypassmeta-analysisrandomized controlled trialstem cell

Identifiers

PMID30906476
PMCPMC6425237

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.