Evidence map›Paper›PMID 30906443›Full record

ArticleExperimental and therapeutic medicine2019

Searching for perturbed biological pathways and genes through analyzing the expression profile changes in osteoclasts after treatment by bisphosphonates.

Long Zhao, Bin Zhang, Feng Wu, Xuan-Huang Chen

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental and therapeutic medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Long ZhaoDepartment of Orthopedics, The First Hospital of Lanzhou University, Lanzhou, Gansu 730000, P.R. China.
Bin ZhangDepartment of Orthopedics, Chinese Medicine Hospital of Xi'an City, Xi'an, Shanxi 710021, P.R. China.
Feng WuDepartment of Rehabilitation Medicine, The Affiliated Hospital of Putian University, Putian, Fujian 351100, P.R. China.
Xuan-Huang ChenDepartment of Orthopedics, The Affiliated Hospital of Putian University, Putian, Fujian 351100, P.R. China.
Putian University · CNLanzhou University · CNShaanxi Provincial Hospital of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Criticality pathways and genes related to osteoporosis were identified. We downloaded the expression data of osteoclasts treated with or without bisphosphonates and all human pathways from the public database. Gibbs sampling and Markov chain were performed to identify the disturbed pathways and the hub genes in the disturbed pathways. Pathways and genes with adjusted probability (

Indexed as

bisphosphonatesGibbs samplingMarkov chainosteoporosis

Identifiers

PMID30906443
PMCPMC6425151
OpenAlexW2914238509

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.