Evidence map›Paper›PMID 30906114›Full record

ArticleJournal of polymer science. Part A, Polymer chemistry2018

Control of Cationic Nanogel PEGylation in Heterogeneous ARGET ATRP Emulsion Polymerization with PEG Macromonomers.

David S Spencer, Bryan C Luu, David W Beckman, Nicholas A Peppas

Abstract read
In one paragraph

Article in Journal of polymer science. Part A, Polymer chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Cytocompatibility, membrane disruption, and siRNA delivery using environmentally responsive cationic nanogels.Journal of controlled release : official journal of the Controlled Release Society · 2021
    Article
  5. Biodegradable cationic nanogels with tunable size, swelling and pKInternational journal of pharmaceutics · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

David S SpencerMcKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, Texas 78712.
Bryan C LuuMcKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, Texas 78712.
David W BeckmanMcKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, Texas 78712.
Nicholas A PeppasMcKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, Texas 78712.ORCID 0000-0002-3522-9513
The University of Texas at Austin · US

Funding

Sensor arrays based on molecularly imprinted polymers for diagnosis of Sjogren's syndromeR01EB022025 · NIBIB · UNIVERSITY OF TEXAS AT AUSTIN · PI ANSLYN, ERIC V., PEPPAS, NICHOLAS A · 2016 to 2019
$1.5M
NIBIB NIH HHS R01 EB022025
6 · The paper itself

Abstract

Crosslinked cationic nanoscale networks with hydrophobic cores are an environmentally robust alternative to self-assembled polymeric drug delivery carriers with respect to therapeutic encapsulation and stability to dilution. However, the ability to tune the degree of PEG incorporated into nanogels during synthesis is more challenging. In this work, biodegradable cationic nanogels were synthesized by ARGET ATRP emulsion polymerization in a single step. The density of PEG in the final nanogels ranged from zero to 40 wt % and was dependent on the feed concentration of PEG monomer, surfactant concentration, surfactant hydrophilic-lipophilic balance, and the ratio of cationic to nonionic surfactant. A comprehensive analysis of nanogel material properties as a function of PEG graft density is presented including analysis of composition, monomer conversion, thermal properties, size, surface charge, and degradation. This study provides a robust analysis for the synthesis of degradable cationic nanogels via a controlled radical polymerization with predictable degrees of PEGylation.

Indexed as

ARGET ATRPbiodegradabledrug deliverynanogelpoly(ethylene glycol)

Identifiers

PMID30906114
PMCPMC6426315
OpenAlexW2801362677

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.