Evidence map›Paper›PMID 30906106›Full record

ArticleCommunications in statistics: theory and methods2017

Conditional moving linear regression: modeling the recruitment process for ALLHAT.

Dejian Lai, Qiang Zhang, Jose-Miguel Yamal, Paula T Einhorn, Barry R Davis, ALLHAT Collaborative Research Group

Abstract read
In one paragraph

Article in Communications in statistics: theory and methods, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dejian LaiCoordinating Center for Clinical Trials, Biostatistics Division, The University of Texas School of Public Health, Houston, TX, United States.
Qiang ZhangNRG Oncology Statistics and Data Management Center, Philadelphia, PA, United States.
Jose-Miguel YamalCoordinating Center for Clinical Trials, Biostatistics Division, The University of Texas School of Public Health, Houston, TX, United States.
Paula T EinhornDivision of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD, United States.
Barry R DavisCoordinating Center for Clinical Trials, Biostatistics Division, The University of Texas School of Public Health, Houston, TX, United States.
ALLHAT Collaborative Research Group

Funding

CLINICAL TRIALS CENTER FOR ALLHAT-N01HC35130-268035130N01HC035130 · HC · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · 1993 to 2005
$6.3M
NHLBI NIH HHS HHSN268201100036CNHLBI NIH HHS N01 HC035130
6 · The paper itself

Abstract

Effective recruitment is a prerequisite for successful execution of a clinical trial. ALLHAT, a large hypertension treatment trial (N = 42, 418), provided an opportunity to evaluate adaptive modeling of recruitment processes using conditional moving linear regression. Our statistical modeling of recruitment, comparing Brownian and fractional Brownian motion, indicates that fractional Brownian motion combined with moving linear regression is better than classic Brownian motion in terms of higher conditional probability of achieving a global recruitment goal in four week ahead projections. Further research is needed to evaluate how recruitment modeling can assist clinical trialists in planning and executing clinical trials.

Indexed as

ALLHATBrownian motionfractional Brownian motionpredictionrecruitment

Identifiers

PMID30906106
PMCPMC6430572

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.