Evidence map›Paper›PMID 30906077›Full record

ArticleTetrahedron letters2018

Stereocontrolled synthesis of four isomeric linoleate triols of relevance to skin barrier formation and function.

Robert W Davis, Alexander Allweil, Jianhua Tian, Alan R Brash, Gary A Sulikowski

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tetrahedron letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Robert W DavisDepartment of Chemistry, Institute of Chemical Biology, Vanderbilt University, Nashville, TN 37235, USA.
Alexander AllweilDepartment of Chemistry, Institute of Chemical Biology, Vanderbilt University, Nashville, TN 37235, USA.
Jianhua TianDepartment of Chemistry, Institute of Chemical Biology, Vanderbilt University, Nashville, TN 37235, USA.
Alan R BrashDepartment of Pharmacology, Institute of Chemical Biology, Vanderbilt University, Nashville, TN 37232, USA.
Gary A SulikowskiDepartment of Chemistry, Institute of Chemical Biology, Vanderbilt University, Nashville, TN 37235, USA.

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MATTHEW J TYSKA · 1995 to 2026
$172.8M
Chemistry-Biology Interface Training GrantT32GM065086 · NIGMS · VANDERBILT UNIVERSITY · PI BACHMANN, BRIAN O, SULIKOWSKI, GARY ALLEN · 2002 to 2022
$7.0M
Linking Lipoxygenases with Essential Fatty Acids and Epidermal Barrier FormationR01AR051968 · NIAMS · VANDERBILT UNIVERSITY · PI BRASH, ALAN R. · 2005 to 2016
$3.0M
Chemistry and Biology of Novel Arachidonic Acid MetabolitesR01GM115722 · NIGMS · VANDERBILT UNIVERSITY · PI SULIKOWSKI, GARY ALLEN · 2015 to 2018
$1.2M
NCI NIH HHS P30 CA068485NIAMS NIH HHS R01 AR051968NIGMS NIH HHS R01 GM115722NIGMS NIH HHS T32 GM065086
6 · The paper itself

Abstract

Linoleate triol esters are intermediates along the pathway of formation of the mammalian skin permeability barrier. In connection with the study of their involvement in barrier formation we required access to isomerically pure and defined samples of four linoleate triol esters. A common synthetic strategy was developed starting from isomeric alkynols derived from d-tartaric acid and 2-deoxy-d-ribose.

Indexed as

Fatty acidsStereochemistrySynthesis strategyTotal synthesis

Identifiers

PMID30906077
PMCPMC6424341

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.