Evidence map›Paper›PMID 30905437›Full record

ArticleCell host & microbe2019

Monocyte-Derived CD11c

Samarchith P Kurup, Scott M Anthony, Lisa S Hancox, Rahul Vijay, Lecia L Pewe, Steven J Moioffer, Ramakrishna Sompallae, Chris J Janse, Shahid M Khan, John T Harty

Open access · bronzeAbstract read
In one paragraph

Article in Cell host & microbe, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 75 citations in OpenAlex.

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  20. CD8Frontiers in immunology · 2024
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Samarchith P KurupDepartment of Microbiology and Immunology, University of Iowa, Iowa City, IA 52242, USA.
Scott M AnthonyDepartment of Microbiology and Immunology, University of Iowa, Iowa City, IA 52242, USA.
Lisa S HancoxDepartment of Microbiology and Immunology, University of Iowa, Iowa City, IA 52242, USA.
Rahul VijayDepartment of Microbiology and Immunology, University of Iowa, Iowa City, IA 52242, USA.
Lecia L PeweDepartment of Microbiology and Immunology, University of Iowa, Iowa City, IA 52242, USA.
Steven J MoiofferDepartment of Microbiology and Immunology, University of Iowa, Iowa City, IA 52242, USA.
Ramakrishna SompallaeDepartment of Pathology, University of Iowa, Iowa City, IA 52242, USA; Iowa Institute of Human Genetics, University of Iowa, Iowa City, IA 52242, USA.
Chris J JanseLeiden Malaria Research Group, Department of Parasitology, Leiden University Medical Center (LUMC), 2333ZA Leiden, the Netherlands.
Shahid M KhanLeiden Malaria Research Group, Department of Parasitology, Leiden University Medical Center (LUMC), 2333ZA Leiden, the Netherlands.
John T HartyDepartment of Microbiology and Immunology, University of Iowa, Iowa City, IA 52242, USA; Department of Pathology, University of Iowa, Iowa City, IA 52242, USA; Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USA. Electronic address: john-harty@uiowa.edu.
University of Iowa · USLeiden University Medical Center · NL

Funding

Regulation of primary and secondary CD4 and CD8 T cell memoryR37AI042767 · NIAID · UNIVERSITY OF IOWA · PI HARTY, JOHN T · 2008 to 2017
$4.7M
T resident memory in the lungR01AI042767 · NIAID · UNIVERSITY OF IOWA · PI HARTY, JOHN T · 1998 to 2023
$4.4M
Memory CD8 T cell immunity to Plasmodium liver stage infecR01AI085515 · NIAID · UNIVERSITY OF IOWA · PI HARTY, JOHN T · 2010 to 2020
$4.1M
Understanding immune regulation in blood-stage malariaR01AI100527 · NIAID · UNIVERSITY OF IOWA · PI HARTY, JOHN T · 2012 to 2021
$3.6M
T cell immunity to Plasmodium sporozoite immunizationR01AI095178 · NIAID · UNIVERSITY OF IOWA · PI HARTY, JOHN T · 2012 to 2016
$2.6M
CD8+ T Cell effector mechanisms against L. monocytogenesR21AI042767 · NIAID · UNIVERSITY OF IOWA · PI HARTY, JOHN T. · 2002 to 2002
$331k
NIAID NIH HHS R01 AI042767NIAID NIH HHS R01 AI085515NIAID NIH HHS R01 AI095178NIAID NIH HHS R01 AI100527NIAID NIH HHS R21 AI042767NIAID NIH HHS R37 AI042767
6 · The paper itself

Abstract

Plasmodium sporozoites inoculated by mosquitoes migrate to the liver and infect hepatocytes prior to release of merozoites that initiate symptomatic blood-stage malaria. Plasmodium parasites are thought to be restricted to hepatocytes throughout this obligate liver stage of development, and how liver-stage-expressed antigens prime productive CD8 T cell responses remains unknown. We found that a subset of liver-infiltrating monocyte-derived CD11c

Indexed as

Antigen PresentationImmunity, CellularCD11c AntigenCD8-Positive T-LymphocytesHepatocytesLiverMalariaMonocytesPlasmodiumCD11c AntigenAPCCD11cCD8dendriticdraininglivermalariaPlasmodiumprimingT cells

Identifiers

PMID30905437
PMCPMC6459714
OpenAlexW2924427355

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.