ArticleNeuron2019
Distinct Cortical-Thalamic-Striatal Circuits through the Parafascicular Nucleus.
Article in Neuron, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers, 1 of them a synthesis that pooled it.
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Who cites it
103 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Clinical neuromodulatory effects of deep brain stimulation in disorder of consciousness: A literature review.CNS neuroscience & therapeutics · 2024Pooled it
- Thalamic projections from the cerebellar nuclei receiving proprioceptive signals from the jaw muscles in rats.Brain structure & function · 2026Article
- Distinct parafascicular neuronal ensembles mediate the sensory and affective dimensions of trigeminal neuralgia.The Journal of clinical investigation · 2026Article
- Brain-wide activity mapping reveals the somatosensory cortex as a sex-specific regulator of hedonic feeding.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Brain injury reactivates a developmental program driving genesis and integration of transient LGE-class interneurons.Stem cell reports · 2026Article
- Vestibular nucleus stimulation for ameliorating locomotor dynamics in a Parkinsonian mouse model.Nature communications · 2026Article
- Targeting the posterior thalamic hub: hemispheric-specific encoding of pain-depression comorbidity after hemorrhagic stroke.BMC medicine · 2026Article
- The parafascicular thalamus steers attention to facilitate learning.bioRxiv : the preprint server for biology · 2026Article
- Genoarchitecture and input-output organization of the mouse basal ganglia and thalamic parafascicular nucleus.Nature neuroscience · 2026Article
- Glutamatergic pathway from deep layers of the insular cortex to the rostral central medial thalamic nucleus participates in neuropathic pain and anxiety-like behaviors in mice.The journal of headache and pain · 2026Article
- Article
- Distinct mediodorsal-prefrontal loops differentially encode reward-predictive cues.bioRxiv : the preprint server for biology · 2026Article
- The parafascicular nucleus of the thalamus orchestrates coordinated skeletomotor, autonomic, and aversive state transitions.bioRxiv : the preprint server for biology · 2026Article
- Complementary cortical and thalamic contributions to cell type-specific striatal activity dynamics during movement.Science advances · 2026Article
- Article
- Mapping the human thalamus: a historical review of thalamic atlases from histology to modern neuroanatomy.Frontiers in neuroanatomy · 2026Review
- Dual cholinergic mechanisms for sculpting striatal dopamine in vivo.bioRxiv : the preprint server for biology · 2025Article
- Aberrant neural activity in the peritumoral cortex underlies the progression of tumor-associated seizures.Nature communications · 2025Article
- Article
- Thalamic nuclei volume changes associated with cognitive and motor manifestations of Parkinson's disease.NPJ Parkinson's disease · 2025Article
43 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors.
Funding
Abstract
The thalamic parafascicular nucleus (PF), an excitatory input to the basal ganglia, is targeted with deep-brain stimulation to alleviate a range of neuropsychiatric symptoms. Furthermore, PF lesions disrupt the execution of correct motor actions in uncertain environments. Nevertheless, the circuitry of the PF and its contribution to action selection are poorly understood. We find that, in mice, PF has the highest density of striatum-projecting neurons among all sub-cortical structures. This projection arises from transcriptionally and physiologically distinct classes of PF neurons that are also reciprocally connected with functionally distinct cortical regions, differentially innervate striatal neurons, and are not synaptically connected in PF. Thus, mouse PF contains heterogeneous neurons that are organized into parallel and independent associative, limbic, and somatosensory circuits. Furthermore, these subcircuits share motifs of cortical-PF-cortical and cortical-PF-striatum organization that allow each PF subregion, via its precise connectivity with cortex, to coordinate diverse inputs to striatum.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.