Evidence map›Paper›PMID 30905258›Full record

ArticleJournal of the American Heart Association2019

Usefulness of Blood Pressure Variability Indices Derived From 24-Hour Ambulatory Blood Pressure Monitoring in Detecting Autonomic Failure.

Hamza A Lodhi, Poghni A Peri-Okonny, Kevin Schesing, Kamal Phelps, Christian Ngo, Hillary Evans, Debbie Arbique, Angela L Price, Steven Vernino, Lauren Phillips and 6 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 34 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Postprandial Hypotension-Methods for the Evaluation and Management.Geriatrics & gerontology international · 2026
    Review
  4. Article
  5. Vasomotor symptoms of menopause, sympathetic activity, and blood pressure in postmenopausal females.American journal of physiology. Heart and circulatory physiology · 2025
    Article
  6. Peripheral autonomic failure is associated with more severe postprandial hypotension compared to central autonomic failure.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025
    Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Abnormal circadian blood pressure regulation and cognitive impairment in α-synucleinopathies.Hypertension research : official journal of the Japanese Society of Hypertension · 2022
    Review
  16. Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Hamza A Lodhi1 Hypertension Section University of Texas Southwestern Medical Center Dallas TX.
Poghni A Peri-Okonny1 Hypertension Section University of Texas Southwestern Medical Center Dallas TX.
Kevin Schesing2 Internal Medicine Department University of Texas Southwestern Medical Center Dallas TX.
Kamal Phelps1 Hypertension Section University of Texas Southwestern Medical Center Dallas TX.
Christian Ngo2 Internal Medicine Department University of Texas Southwestern Medical Center Dallas TX.
Hillary Evans2 Internal Medicine Department University of Texas Southwestern Medical Center Dallas TX.
Debbie Arbique1 Hypertension Section University of Texas Southwestern Medical Center Dallas TX.
Angela L Price1 Hypertension Section University of Texas Southwestern Medical Center Dallas TX.
Steven Vernino3 Department of Neurology and Neurotherapeutics University of Texas Southwestern Medical Center Dallas TX.
Lauren Phillips3 Department of Neurology and Neurotherapeutics University of Texas Southwestern Medical Center Dallas TX.
Jere H Mitchell4 Cardiology Division University of Texas Southwestern Medical Center Dallas TX.
Scott A Smith5 Department of Health Care Sciences University of Texas Southwestern Medical Center Dallas TX.
Yuichiro Yano6 Department of Community and Family Medicine Duke University Durham NC.
Sandeep R Das4 Cardiology Division University of Texas Southwestern Medical Center Dallas TX.
Tao Wang7 Quantitative Biomedical Research Center University of Texas Southwestern Medical Center Dallas TX.
Wanpen Vongpatanasin1 Hypertension Section University of Texas Southwestern Medical Center Dallas TX.
The University of Texas Southwestern Medical Center · USDuke University · US

Funding

UT Southwestern Medical Center Simmons Comprehensive Cancer CenterP30CA142543 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Sandi Leigh Pruitt · 2010 to 2026
$53.7M
UT Southwestern O'Brien Kidney Research Core CenterP30DK079328 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI MOE, ORSON W · 2007 to 2021
$16.9M
RENAL CONTROL OF BODY COMPOSITION AND BLOOD PRESSURET32DK007257 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI BAUM, MICHEL GERARD, MOE, ORSON W · 1986 to 2021
$5.0M
Development of integrative models for early liver toxicity assessmentR03ES026397 · NIEHS · UT SOUTHWESTERN MEDICAL CENTER · PI WANG, TAO · 2016 to 2017
$162k
NCI NIH HHS P30 CA142543NIDDK NIH HHS P30 DK079328NIDDK NIH HHS T32 DK007257NIEHS NIH HHS R03 ES026397
6 · The paper itself

Abstract

Background Increased blood pressure ( BP ) variability and nondipping status seen on 24-hour ambulatory BP monitoring are often observed in autonomic failure ( ATF ). Methods and Results We assessed BP variability and nocturnal BP dipping in 273 patients undergoing ambulatory BP monitoring at Southwestern Medical Center between 2010 and 2017. SD , average real variability, and variation independent of mean were calculated from ambulatory BP monitoring. Patients were divided into a discovery cohort (n=201) and a validation cohort (n=72). ATF was confirmed by formal autonomic function test. In the discovery cohort, 24-hour and nighttime average real variability, SD , and variation independent of mean did not differ significantly between ATF (n=25) and controls (n=176, all P>0.05). However, daytime SD, daytime coefficient of variation, and daytime variation independent of mean of systolic BP ( SBP ) were all significantly higher in patients with ATF than in controls in both discovery and validation cohorts. Nocturnal BP dipping was more blunted in ATF patients than controls in both cohorts (both P<0.01). Using the threshold of 16 mm Hg, daytime SD SBP yielded a sensitivity of 77% and specificity of 82% in detecting ATF in the validation cohort, whereas nondipping status had a sensitivity of 80% and specificity of 44%. The area under the receiver operator characteristic of daytime SD SBP was greater than the area under the receiver operator characteristic of nocturnal SBP dipping (0.79 [0.66-0.91] versus 0.73 [0.58-0.87], respectively). Conclusions Daytime SD of SBP is a better screening tool than nondipping status in detecting autonomic dysfunction.

Indexed as

AgedAged, 80 and overAutonomic Nervous System DiseasesBlood Pressure Monitoring, AmbulatoryCase-Control StudiesDiabetic NeuropathiesDysautonomia, FamilialFemaleHumansMaleMiddle AgedMultiple System AtrophyParkinson DiseasePrimary DysautonomiasPure Autonomic FailureSensitivity and Specificityambulatory blood pressure monitoringautonomic functionblood pressure variabilityhypertensionlabile hypertensionorthostatic hypotension

Identifiers

PMID30905258
PMCPMC6509738
OpenAlexW2925309926

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.