ArticleJournal of the American Chemical Society2019
Electrochemically Driven, Ni-Catalyzed Aryl Amination: Scope, Mechanism, and Applications.
Article in Journal of the American Chemical Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
96 citing papers in PubMed.
- The Preparation and Systematic Evaluation of Ligated Ni(II) Pre-Catalysts (NiPC) in Common Single Electron Cross-Coupling Reactions.ACS medicinal chemistry letters · 2026Article
- Base-Free C-N Cross-Electrophile Coupling.Journal of the American Chemical Society · 2026Article
- Nickel Foam Electrodes-A Versatile, Powerful, and Readily Available Tool in Electro-Organic Synthesis.Chemical record (New York, N.Y.) · 2026Review
- Development of Kilogram-Scale Electrochemical Ni-Catalyzed Cross Electrophile Coupling in Flow.Organic process research & development · 2026Article
- Advances in electrochemical peptide synthesis and modification.Nature reviews. Chemistry · 2026Review
- Synergistic Fe/Ni catalysis for electrochemical 1,1-difunctionalization of alkenes.Nature communications · 2026Article
- Photochemical, electrochemical and electrophotochemical C-N bond-forming cross-coupling reactions.Nature reviews. Chemistry · 2026Review
- Review
- General and selective nickel-electrocatalyzed cross-electrophile C*(Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Advances in NiACS catalysis · 2026Review
- Recent Advancements in Nickel-Catalyzed Electrochemical Reductive Cross-Coupling.ACS organic & inorganic Au · 2025Review
- Deciphering the Synchronization of Alternating Current Frequency with the Nickel Catalytic Cycle in Selective C-N Cross-Coupling.Journal of the American Chemical Society · 2025Article
- Reactivity Studies of Bipyridine-Ligated Nickel(I) and Nickel(0) Complexes Inform the Mechanism in Modern Cross-Coupling Reactions.Journal of the American Chemical Society · 2025Article
- 2-Substituted vs 2,9-Disubstituted Phenanthroline-NiInorganic chemistry · 2025Article
- Photoelectrochemistry-Promoted Ni-Catalyzed C-O Cross-Couplings.Precision chemistry · 2025Article
- Advances in Copper and Nickel C─N and C─O Cross-Couplings of (Hetero)Aryl Chlorides Enabled by Ancillary Ligand Development.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Review
- LMCT-driven electron relay unlocks alcohols as tunable reductants for nickel-catalyzed cross-electrophilic couplings.Nature communications · 2025Article
- Indole Photocatalysts and Secondary Amine Ligands Enable Nickel-Photoredox C(spACS catalysis · 2025Article
- Antioxidants: a comprehensive review.Archives of toxicology · 2025Review
- Evidence for a Unifying NiJournal of the American Chemical Society · 2025Article
36 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
24 authors.
Funding
Abstract
C-N cross-coupling is one of the most valuable and widespread transformations in organic synthesis. Largely dominated by Pd- and Cu-based catalytic systems, it has proven to be a staple transformation for those in both academia and industry. The current study presents the development and mechanistic understanding of an electrochemically driven, Ni-catalyzed method for achieving this reaction of high strategic importance. Through a series of electrochemical, computational, kinetic, and empirical experiments, the key mechanistic features of this reaction have been unraveled, leading to a second generation set of conditions that is applicable to a broad range of aryl halides and amine nucleophiles including complex examples on oligopeptides, medicinally relevant heterocycles, natural products, and sugars. Full disclosure of the current limitations and procedures for both batch and flow scale-ups (100 g) are also described.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.