Evidence map›Paper›PMID 30905148›Full record

ArticleJournal of the American Chemical Society2019

Enzyme-Catalyzed Inverse-Electron Demand Diels-Alder Reaction in the Biosynthesis of Antifungal Ilicicolin H.

Zhuan Zhang, Cooper S Jamieson, Yi-Lei Zhao, Dehai Li, Masao Ohashi, K N Houk, Yi Tang

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
12.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 120 citations in OpenAlex.

  1. Review
  2. Draft genome sequence of mangrove-isolated fungusMicrobiology resource announcements · 2026
    Article
  3. Review
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  5. Mycology · 2025
    Article
  6. Arcopilins: A New Family ofJournal of medicinal chemistry · 2024
    Article
  7. Article
  8. Review
  9. A Novel ZnMicroorganisms · 2023
    Article
  10. Natural product reports · 2023
    Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. EnzymaticJournal of the American Chemical Society · 2023
    Article
  16. Review
  17. Review
  18. Review
  19. Unraveling the biosynthesis of penicillenols by genome mining PKS-NRPS gene clusters inAIChE journal. American Institute of Chemical Engineers · 2022
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Zhuan Zhang
Cooper S Jamieson
Yi-Lei ZhaoState Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, MOE-LSB and MOE-LSC, School of Life Sciences and Biotechnology , Shanghai Jiao Tong University , Shanghai 200240 , China.ORCID 0000-0003-4687-7847
Dehai LiKey Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Laboratory for Marine Drugs and Bioproducts, Pilot National Laboratory for Marine Science and Technology , Ocean University of China , Qingdao 266003 , China.ORCID 0000-0002-7191-2002
Masao Ohashi
University of California, Los Angeles · USQingdao National Laboratory for Marine Science and Technology · CN

Funding

Biosynthesis and Enzymology of Antifungal Natural Products - R01AI141481R01AI141481 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GARG, NEIL K, HOUK, KENDALL N · 2019 to 2023
$2.8M
Steroselectivity of Synthetically Valuable Enzyme CatalystsR01GM124480 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HOUK, KENDALL N · 2018 to 2021
$1.1M
NIAID NIH HHS R01 AI141481NIGMS NIH HHS R01 GM124480
6 · The paper itself

Abstract

The pericyclases are a growing superfamily of enzymes that catalyze pericyclic reactions. We report a pericyclase IccD catalyzing an inverse-electron demand Diels-Alder (IEDDA) reaction with a rate acceleration of 3 × 10

Indexed as

BiocatalysisAntifungal AgentsBenzaldehydesCycloaddition ReactionElectron TransportEnzymesModels, MolecularMolecular ConformationAntifungal AgentsBenzaldehydesEnzymesilicicolin H

Identifiers

PMID30905148
PMCPMC6585442
OpenAlexW2924613290

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.