Evidence map›Paper›PMID 30905023›Full record

ArticleMolecular and cellular biochemistry2019

Hypolipidemic effect of novel 2,5-bis(4-hydroxybenzylidenamino)-1,3,4-thiadiazole as potential peroxisome proliferation-activated receptor-α agonist in acute hyperlipidemic rat model.

Lama A Hamadneh, Dima A Sabbah, Suhair J Hikmat, Luma A Al-Samad, Mariam Hasan, Tariq M Al-Qirim, Imad M Hamadneh, Ammar H Al-Dujaili

Abstract read
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In one paragraph

Article in Molecular and cellular biochemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lama A HamadnehFaculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman, Jordan. lama.hamadneh@zuj.edu.jo.ORCID http://orcid.org/0000-0003-4672-3303
Dima A SabbahFaculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman, Jordan.
Suhair J HikmatFaculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman, Jordan.
Luma A Al-SamadFaculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman, Jordan.
Mariam HasanFaculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman, Jordan.
Tariq M Al-QirimFaculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman, Jordan.
Imad M HamadnehDepartment of Chemistry, Faculty of Science, University of Jordan, Amman, Jordan.
Ammar H Al-DujailiHamdi Mango Center for Scientific Research, University of Jordan, Amman, Jordan.

Funding

Al-Zaytoonah University of Jordan 13/10/2016
6 · The paper itself

Abstract

The development of new antihyperlipidemic agents with higher potency and lower side effects is of high priority. In this study, 1,3,4 thiadiazole Schiff base derivatives were synthesized as potential peroxisome proliferation-activated receptor-α (PPARα) agonists and characterized using elemental analysis, FTIR,

Indexed as

Hypolipidemic AgentsThiadiazolesAcute DiseaseAnimalsDisease Models, AnimalGene Expression RegulationHyperlipidemiasMalePPAR alphaRatsRats, Sprague-DawleySignal Transduction1,3,4-thiadiazoleHypolipidemic AgentsPPAR alphaThiadiazoles1,3,4 Thiadiazole derivativesGene arrayPeroxisome proliferation-activated receptor-αSchiff baseTriglycerides

Identifiers

PMID30905023

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.