Evidence map›Paper›PMID 30904963›Full record

ReviewBiomedical microdevices2019

Engineered microscale hydrogels for drug delivery, cell therapy, and sequencing.

Marissa E Wechsler, Regan E Stephenson, Andrew C Murphy, Heidi F Oldenkamp, Ankur Singh, Nicholas A Peppas

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biomedical microdevices, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Recent Developments in Nanoparticle-Hydrogel Hybrid Materials for Controlled Release.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
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  11. Article
  12. Article
  13. Review
  14. Synthesis of Novel Tamarind Gum-Gels (Basel, Switzerland) · 2021
    Article
  15. Article
  16. Rational Design of Immunomodulatory Hydrogels for Chronic Wound Healing.Advanced materials (Deerfield Beach, Fla.) · 2021
    Review
  17. Charged Poly(ACS biomaterials science & engineering · 2021
    Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Marissa E WechslerDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA.
Regan E StephensonMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
Andrew C MurphyInstitute for Biomaterials, Drug Delivery, and Regenerative Medicine, The University of Texas at Austin, Austin, TX, USA.
Heidi F OldenkampInstitute for Biomaterials, Drug Delivery, and Regenerative Medicine, The University of Texas at Austin, Austin, TX, USA.
Ankur SinghMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
Nicholas A PeppasDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA. peppas@che.utexas.edu.

Funding

Biomaterials-based Germinal Center Niches for Understanding the B Cell Maturation and B cell receptor signalingR01AI132738 · NIAID · GEORGIA INSTITUTE OF TECHNOLOGY · PI SINGH, ANKUR · 2018 to 2022
$1.9M
Sensor arrays based on molecularly imprinted polymers for diagnosis of Sjogren's syndromeR01EB022025 · NIBIB · UNIVERSITY OF TEXAS AT AUSTIN · PI ANSLYN, ERIC V., PEPPAS, NICHOLAS A · 2016 to 2019
$1.5M
LETSSGo: Lymphoma-on-chip Engineered Technology for Single-Organoid Sequencing and GenomicsR33CA212968 · NCI · CORNELL UNIVERSITY · PI SINGH, ANKUR · 2017 to 2019
$1.1M
NCI NIH HHS R33 CA212968NIAID NIH HHS R01 AI132738NIBIB NIH HHS R01 EB022025
6 · The paper itself

Abstract

Engineered microscale hydrogels have emerged as promising therapeutic approaches for the treatment of various diseases. These microgels find wide application in the biomedical field because of the ease of injectability, controlled release of therapeutics, flexible means of synthesis, associated tunability, and can be engineered as stimuli-responsive. While bulk hydrogels of several length-scale dimensions have been used for over two decades in drug delivery applications, their use as microscale carriers of drug and cell-based therapies is relatively new. Herein, we critically summarize the fundamentals of hydrogels based on their equilibrium and dynamics of their molecular structure, as well as solute diffusion as it relates to drug delivery. In addition, examples of common microgel synthesis techniques are provided. The ability to tune microscale hydrogels to obtain controlled release of therapeutics is discussed, along with microgel considerations for cell encapsulation as it relates to the development of cell-based therapies. We conclude with an outlook on the use of microgels for cell sequencing, and the convergence of the use of microscale hydrogels for drug delivery, cell therapy, and cell sequencing based systems.

Indexed as

EngineeringHydrogelsCell- and Tissue-Based TherapyDrug Delivery SystemsHumansMicrotechnologySequence AnalysisHydrogelsCell therapyDrug deliveryHydrogelsSequencing

Identifiers

PMID30904963
PMCPMC6615733

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.