Evidence map›Paper›PMID 30904821›Full record

ReviewCurrent opinion in structural biology2019

Postsynaptic protein organization revealed by electron microscopy.

Yun-Tao Liu, Chang-Lu Tao, Pak-Ming Lau, Z Hong Zhou, Guo-Qiang Bi

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current opinion in structural biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Junctions in Jeopardy: the neuromuscular junction is a selective pathological target in Charcot-Marie-Tooth disease.Mammalian genome : official journal of the International Mammalian Genome Society · 2026
    Review
  2. Article
  3. Article
  4. Article
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  6. Article
  7. Structural and functional imaging of brains.Science China. Chemistry · 2023
    Review
  8. Article
  9. Review
  10. Article
  11. Neurons as a model system for cryo-electron tomography.Journal of structural biology: X · 2022
    Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Mesophasic organization of GABANature neuroscience · 2020
    Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yun-Tao LiuCenter for Integrative Imaging, Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, Anhui, China; School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, China.
Chang-Lu TaoCenter for Integrative Imaging, Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, Anhui, China; School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, China.
Pak-Ming LauCenter for Integrative Imaging, Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, Anhui, China; School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, China.
Z Hong ZhouThe California NanoSystems Institute, University of California, Los Angeles, CA, USA; Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, CA, USA.
Guo-Qiang BiCenter for Integrative Imaging, Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, Anhui, China; School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, China; CAS Center for Excellence in Brain Science and Intelligence Technology, University of Science and Technology of China, Hefei, Anhui, China. Electronic address: gqbi@ustc.edu.cn.

Funding

High-Resolution CryoEM Reconstruction of Large ComplexesR01GM071940 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ZHOU, Z HONG · 2006 to 2025
$5.0M
NIGMS NIH HHS R01 GM071940
6 · The paper itself

Abstract

Neuronal synapses are key devices for transmitting and processing information in the nervous system. Synaptic plasticity, generally regarded as the cellular basis of learning and memory, involves changes of subcellular structures that take place at the nanoscale. High-resolution imaging methods, especially electron microscopy (EM), have allowed for quantitative analysis of such nanoscale structures in different types of synapses. In particular, the semi-ordered organization of neurotransmitter receptors and their interacting scaffolds in the postsynaptic density have been characterized for both excitatory and inhibitory synapses by studies using various EM techniques such as immuno-EM, electron tomography of high-pressure freezing and freeze-substituted samples, and cryo electron tomography. These techniques, in combination with new correlative approaches, will further facilitate our understanding of the molecular organization underlying diverse functions of neuronal synapses.

Indexed as

Microscopy, ElectronAnimalsgamma-Aminobutyric AcidHumansMembrane ProteinsReceptors, NeurotransmitterSynapsesgamma-Aminobutyric AcidMembrane ProteinsReceptors, Neurotransmitter

Identifiers

PMID30904821
PMCPMC6753054

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.