Evidence map›Paper›PMID 30904732›Full record

ArticleJournal of critical care2019

Systemic response of coated-platelet and peripheral blood inflammatory cell indices after aneurysmal subarachnoid hemorrhage and long-term clinical outcome.

Bappaditya Ray, Stephen R Ross, Gopichand Danala, Faranak Aghaei, Claire Delpirou Nouh, Lance Ford, Kimberly M Hollabaugh, Brittany N Karfonta, Joshua A Santucci, Benjamin O Cornwell and 4 more

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of critical care, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07354321 (Thrombo-inflammation Des Maladies Neurovascualires aiguës), which is not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07354321 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Thrombo-inflammation Des Maladies Neurovascualires aiguës : définition de Nouvelles Cibles thérapeutiques (TARGETS)

TypeobservationalSponsorFrançois DelvoyeRan2026 to 2032Enrolled499ConditionsDelayed Cerebral Ischemia After Subarachnoid Hemorrhage, Ischemic Stroke of Large or Medium Vessels
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Microthrombi and hypercoagulability's contribution to delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Review
  4. Review
  5. Observational
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  9. Identifying risk factors for perioperative thromboembolic complications in patients treated with the Woven EndoBridge device.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2023
    Article
  10. Systemic Inflammation after Aneurysmal Subarachnoid Hemorrhage.International journal of molecular sciences · 2023
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Bappaditya RayDepartments of Neurology, College of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. Electronic address: Bappaditya-Ray@ouhsc.edu.
Stephen R RossDepartments of Neurology, College of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Gopichand DanalaElectrical Engineering, University of Oklahoma, Norman, OK, USA.
Faranak AghaeiElectrical Engineering, University of Oklahoma, Norman, OK, USA.
Claire Delpirou NouhDepartments of Neurology, College of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Lance FordBiostatistics & Epidemiology, College of Public Health, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Kimberly M HollabaughBiostatistics & Epidemiology, College of Public Health, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Brittany N KarfontaDepartments of Neurology, College of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Joshua A SantucciDepartments of Neurology, College of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Benjamin O CornwellRadiology, College of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Bradley N BohnstedtNeurosurgery, College of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Bin ZhengElectrical Engineering, University of Oklahoma, Norman, OK, USA.
George L DaleInternal Medicine, College of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Calin I ProdanDepartments of Neurology, College of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
University of Oklahoma Health Sciences Center · USUniversity of Oklahoma · US

Funding

Stroke and Coated-Platelets - A Translational Research InitiativeI01CX000340 · VA · OKLAHOMA CITY VA MEDICAL CENTER · PI PRODAN, CALIN IOAN · 2011 to 2025
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CSRD VA I01 CX000340
6 · The paper itself

Abstract

purposePost-hemorrhage period after aneurysmal subarachnoid hemorrhage (aSAH) has several systemic manifestations including prothrombotic and pro-inflammatory states. Inter-relationship between these states using established/routine laboratory biomarkers and its long-term effect on clinical outcome is not well-defined. MATERIALS AND

methodsRetrospective analysis of prospective cohort of 44 aSAH patients. Trend of procoagulant biomarkers [coated-platelets, mean platelet volume to platelet count (MPV:PLT)] and peripheral inflammatory biomarkers [platelet-lymphocyte ratio (PLR), neutrophil-platelet ratio (NLR)] were analyzed using regression analysis. Occurrence of delayed cerebral ischemia (DCI), modified Rankin score (mRS) of 3-6 and Montreal cognitive assessment (MoCA) of <26 at 1-year defined adverse clinical outcome.

resultsPatients with worse mRS and MoCA score had higher rise in coated-platelet compared to those with better scores [20.4 (IQR: 15.6, 32.9) vs. 10.95 (IQR: 6.1, 18.9), p = 0.003] and [16.9 (IQR: 13.4, 28.1) vs. 10.95 (IQR: 6.35, 18.65), p = 0.02] respectively. NLR and PLR trends showed significant initial decline followed by a gradual rise in NLR among those without DCI as compared to persistent low levels in those developing DCI (0.13 units/day vs. -0.07 units/day, p = 0.06).

conclusionsCoated-platelet rise after aSAH is associated with adverse long-term clinical outcome. NLR and PLR trends show an early immune-depressed state after aSAH.

Indexed as

AdultAgedAneurysmBiomarkersBlood PlateletsBrain IschemiaFemaleHumansInflammationLymphocytesMaleMean Platelet VolumeMiddle AgedPlatelet CountProspective StudiesRegression AnalysisBiomarkersHemorrhagic strokeLong-term stroke morbidityNeutrophil-lymphocyte ratioPlatelet-lymphocyte ratioReactive platelets

Identifiers

PMID30904732
PMCPMC8663918
OpenAlexW2921759217

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.