Evidence map›Paper›PMID 30904585›Full record

ArticleNanomedicine : nanotechnology, biology, and medicine2019

Inactivation of common hospital acquired pathogens on surfaces and in air utilizing engineered water nanostructures (EWNS) based nano-sanitizers.

Nachiket Vaze, Georgios Pyrgiotakis, James McDevitt, Lucas Mena, Adler Melo, Alice Bedugnis, Lester Kobzik, Mary Eleftheriadou, Philip Demokritou

Abstract read
In one paragraph

Article in Nanomedicine : nanotechnology, biology, and medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

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  12. Mechanisms underlying inactivation of SARS-CoV-2 by nano-sized electrostatic atomized water particles.Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nachiket VazeCenter for Nanotechnology and Nanotoxicology, Department of Environmental Health, Harvard, T. H. Chan School of Public Health, Harvard University, Boston, MA, USA.
Georgios PyrgiotakisCenter for Nanotechnology and Nanotoxicology, Department of Environmental Health, Harvard, T. H. Chan School of Public Health, Harvard University, Boston, MA, USA.
James McDevittCenter for Nanotechnology and Nanotoxicology, Department of Environmental Health, Harvard, T. H. Chan School of Public Health, Harvard University, Boston, MA, USA.
Lucas MenaCenter for Nanotechnology and Nanotoxicology, Department of Environmental Health, Harvard, T. H. Chan School of Public Health, Harvard University, Boston, MA, USA.
Adler MeloCenter for Nanotechnology and Nanotoxicology, Department of Environmental Health, Harvard, T. H. Chan School of Public Health, Harvard University, Boston, MA, USA.
Alice BedugnisCenter for Nanotechnology and Nanotoxicology, Department of Environmental Health, Harvard, T. H. Chan School of Public Health, Harvard University, Boston, MA, USA.
Lester KobzikCenter for Nanotechnology and Nanotoxicology, Department of Environmental Health, Harvard, T. H. Chan School of Public Health, Harvard University, Boston, MA, USA.
Mary EleftheriadouCenter for Nanotechnology and Nanotoxicology, Department of Environmental Health, Harvard, T. H. Chan School of Public Health, Harvard University, Boston, MA, USA; School of Sciences, European University Cyprus, Nicosia, Cyprus.
Philip DemokritouCenter for Nanotechnology and Nanotoxicology, Department of Environmental Health, Harvard, T. H. Chan School of Public Health, Harvard University, Boston, MA, USA. Electronic address: pdemokri@hsph.harvard.edu.

Funding

Inactivation of ambient virues using Engineered Water NanostructuresR21AI119481 · NIAID · HARVARD SCHOOL OF PUBLIC HEALTH · PI DEMOKRITOU, PHILIP · 2015 to 2016
$438k
NIAID NIH HHS R21 AI119481
6 · The paper itself

Abstract

Infectious diseases represent a major public health challenge worldwide. There are various modes for the transmission of these diseases, with surface and airborne transmission being two of the most important ones. The inefficiencies of current intervention methods have resulted in the emergence of nosocomial infections. Here, we report the use of a nanotechnology based antimicrobial platform using Engineered Water Nanostructures (EWNS) generated using a combined electrospray and ionization of an aqueous suspension of various active ingredients (AIs). These EWNS based nano-sanitizers were tested in terms of their ability to efficiently deliver AI and inactivate Acinetobacter baumannii and influenza H1N1/PR/8 on both surfaces and air. Results indicate a significant reduction in the concertation of the pathogens, while the delivered to pathogen AI doses required for inactivation were miniscule (nanogram level), indicating the viability of such nano-carrier platform as an intervention technology against infectious microorganisms.

Indexed as

HospitalsNanotechnologyWaterAirAnti-Infective AgentsMicrobial ViabilityNanostructuresSurface PropertiesAnti-Infective AgentsWaterAirborne influenzaEngineered water nanostructuresNano-carrierNosocomial infections

Identifiers

PMID30904585
PMCPMC6588479

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.