Evidence map›Paper›PMID 30904580›Full record

ArticleAnnals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology2019

Association between fungal spore exposure in inner-city schools and asthma morbidity.

Sachin N Baxi, William J Sheehan, Joanne E Sordillo, Michael L Muilenberg, Christine A Rogers, Jonathan M Gaffin, Perdita Permaul, Peggy S Lai, Margee Louisias, Carter R Petty and 3 more

Open access · greenAbstract read
In one paragraph

Article in Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 58 citations in OpenAlex.

  1. Review
  2. Review
  3. Medicina (Kaunas, Lithuania) · 2025
    Review
  4. Indoor bioaerosols and asthma: Overview, implications, and mitigation strategies.The Journal of allergy and clinical immunology · 2025
    Review
  5. The Impact of the Indoor Environment on Childhood Asthma.Current allergy and asthma reports · 2025
    Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Optimization ofJournal of fungi (Basel, Switzerland) · 2023
    Article
  13. Review
  14. Article
  15. Article
  16. HEPA filtration intervention in classrooms may improve some students' asthma.The Journal of asthma : official journal of the Association for the Care of Asthma · 2023
    Article
  17. Article
  18. Environmental Exposures Impact Pediatric Asthma Within the School Environment.Immunology and allergy clinics of North America · 2022
    Review
  19. The Environmental Microbiome, Allergic Disease, and Asthma.The journal of allergy and clinical immunology. In practice · 2022
    Article
  20. Update on indoor allergens and their impact on pediatric asthma.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2022
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Sachin N BaxiBoston Children's Hospital, Division of Allergy and Immunology, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts.
William J SheehanBoston Children's Hospital, Division of Allergy and Immunology, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts.
Joanne E SordilloChanning Laboratory, Brigham and Women's Hospital, Boston, Massachusetts.
Michael L MuilenbergDivision of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts, Amherst, Massachusetts.
Christine A RogersDivision of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts, Amherst, Massachusetts.
Jonathan M GaffinHarvard Medical School, Boston, Massachusetts; Boston Children's Hospital, Division of Respiratory Diseases, Boston, Massachusetts.
Perdita PermaulHarvard Medical School, Boston, Massachusetts; Massachusetts General Hospital, Division of Pediatric Allergy and Immunology, Boston, Massachusetts.
Peggy S LaiHarvard Medical School, Boston, Massachusetts; Massachusetts General Hospital, Division of Pulmonary and Critical Care, Boston, Massachusetts.
Margee LouisiasBrigham and Women's Hospital, Boston, Massachusetts.
Carter R PettyBrigham and Women's Hospital, Boston, Massachusetts; Boston Children's Hospital, Clinical Research Center Boston, Massachusetts.
Chunxia FuBrigham and Women's Hospital, Boston, Massachusetts.
Diane R GoldHarvard Medical School, Boston, Massachusetts; Brigham and Women's Hospital, Boston, Massachusetts.
Wanda PhipatanakulBoston Children's Hospital, Division of Allergy and Immunology, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts. Electronic address: wanda.phipatanakul@childrens.harvard.edu.
Brigham and Women's Hospital · USBoston Children's Hospital · USHarvard University · USMassachusetts General Hospital · USUniversity of Massachusetts Amherst · US

Funding

Harvard Clinical and Translational Science Center (UL1)UL1TR000170 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2012 to 2013
$31.4M
SICAS- Diversity SupplementU01AI110397 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI PHIPATANAKUL, WANDA · 2015 to 2020
$8.8M
AsthmaNet: Brigham and Women's Hospital & Children's Hospital BostonU10HL098102 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI ISRAEL, ELLIOT, PHIPATANAKUL, WANDA · 2009 to 2015
$5.5M
ALLERGENS IN INNER-CITY SCHOOLS AND CHILDHOOD ASTHMAR01AI073964 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI PHIPATANAKUL, WANDA · 2008 to 2012
$4.6M
Mentored Career Development for Child and Family Centered Outcomes ResearchK12HS022986 · AHRQ · BOSTON CHILDREN'S HOSPITAL · PI FINKELSTEIN, JONATHAN A · 2014 to 2018
$3.8M
The school microbiome and asthma morbidity in inner-city childrenR01AI144119 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI LAI, PEGGY SUE · 2019 to 2023
$3.7M
Indoor Air Quality and Respiratory Morbidity in School-Aged Children with Bronchopulmonary DysplasiaR01ES030100 · NIEHS · BOSTON CHILDREN'S HOSPITAL · PI GAFFIN, JONATHAN MARK · 2019 to 2023
$3.7M
Environmental Risk Factors for Pediatric Sleep Disordered BreathingR01HL137192 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI PHIPATANAKUL, WANDA · 2017 to 2020
$3.5M
Age-Dependent Pharmacogenomics of Asthma Treatment (ADAPT)R01HD085993 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI WU, ANN CHEN · 2016 to 2020
$3.1M
Midcareer Investigator Award: Urban School Allergen Exposures and Childhood AsthmK24AI106822 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI PHIPATANAKUL, WANDA · 2013 to 2022
$1.9M
Atopy, Leptin and Potential Biomarkers of Comorbid Obesity and Asthma in Inner-City SchoolchildrenK23AI123517 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI PERMAUL, PERDITA · 2017 to 2021
$1.1M
Role of Peanut Allergen in Urban Schools and PreschoolsK23AI104780 · NIAID · CHILDREN'S RESEARCH INSTITUTE · PI SHEEHAN, WILLIAM JAMES · 2014 to 2018
$912k
AHRQ HHS K12 HS022986NCATS NIH HHS UL1 TR000170NHLBI NIH HHS R01 HL137192NHLBI NIH HHS U10 HL098102NIAID NIH HHS K23 AI104780NIAID NIH HHS K23 AI106945NIAID NIH HHS K23 AI123517NIAID NIH HHS K24 AI106822NIAID NIH HHS L40 AI107923NIAID NIH HHS R01 AI073964NIAID NIH HHS R01 AI144119NIAID NIH HHS U01 AI110397NIEHS NIH HHS K23 ES023700NIEHS NIH HHS R01 ES030100
6 · The paper itself

Abstract

backgroundHome fungus exposures may be associated with development or worsening of asthma. Little is known about the effects of school/classroom fungus exposures on asthma morbidity in students.

objectiveTo evaluate the association of school-based fungus exposures on asthma symptoms in both fungus-sensitized and nonsensitized students with asthma.

methodsIn this prospective study, 280 children with asthma from 37 inner-city schools were phenotypically characterized at baseline and followed-up for 1 year. Fungal spores were collected by using a Burkard air sampler twice during the school year. Clinical outcomes were evaluated throughout the school year and linked to classroom-specific airborne spore sampling. The primary outcome was days with asthma symptoms per 2-week period.

resultsFungal spores were present in all classroom samples. The geometric mean of the total fungi was 316.9 spores/m

conclusionChildren with asthma who are sensitized to Alternaria and exposed to this fungus in their classroom may have significantly more days with asthma symptoms than those who were sensitized and not exposed. CLINICAL

trial registrationClinicaltrials.govNCT01756391.

Indexed as

Urban PopulationAir MicrobiologyAir Pollution, IndoorAllergensAlternariaAsthmaChildChild, PreschoolEnvironmental ExposureFemaleHumansHypersensitivityMaleProspective StudiesSchoolsSpores, FungalAllergens

Identifiers

PMID30904580
PMCPMC6555650
OpenAlexW2924428025

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.