Evidence map›Paper›PMID 30904423›Full record

ArticleBrain stimulation

Consistent linear and non-linear responses to invasive electrical brain stimulation across individuals and primate species with implanted electrodes.

Ishita Basu, Madeline M Robertson, Britni Crocker, Noam Peled, Kara Farnes, Deborah I Vallejo-Lopez, Helen Deng, Matthew Thombs, Clarissa Martinez-Rubio, Jennifer J Cheng and 6 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain stimulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 53 citations in OpenAlex.

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  10. Journal of neural engineering · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Ishita BasuNayef Al-Rodhan Laboratories, Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, 02129, USA.
Madeline M RobertsonNayef Al-Rodhan Laboratories, Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Britni CrockerDepartment of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA.
Noam PeledDepartment of Radiology, MGH/HST Martinos Center for Biomedical Imaging, Charlestown, MA, 02129, USA.
Kara FarnesNayef Al-Rodhan Laboratories, Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA.
Deborah I Vallejo-LopezDepartment of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA.
Helen DengNayef Al-Rodhan Laboratories, Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Department of Radiology, MGH/HST Martinos Center for Biomedical Imaging, Charlestown, MA, 02129, USA.
Matthew ThombsNayef Al-Rodhan Laboratories, Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Clarissa Martinez-RubioNayef Al-Rodhan Laboratories, Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Jennifer J ChengNayef Al-Rodhan Laboratories, Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Eric McDonaldNayef Al-Rodhan Laboratories, Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Darin D DoughertyDepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, 02129, USA.
Emad N EskandarNayef Al-Rodhan Laboratories, Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Alik S WidgeDepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, 02129, USA; Picower Institute for Learning & Memory, Massachusetts Institute of Technology, Cambridge, MA 02124, USA.
Angelique C PaulkNayef Al-Rodhan Laboratories, Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address: apaulk@mgh.harvard.edu.
Sydney S CashDepartment of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA.
Harvard University · USMassachusetts General Hospital · USAthinoula A. Martinos Center for Biomedical Imaging · US

Funding

Using microstimulation to map prefrontal fear modules in the ratP50MH086400 · NIMH · UNIVERSITY OF ROCHESTER · PI HABER, SUZANNE N · 2009 to 2013
$10.3M
Multi-Site Non-Invasive Magnetothermal Excitation and Inhibition of Deep Brain StructuresR01MH111872 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ANIKEEVA, POLINA O, PRALLE, ARND · 2016 to 2019
$3.6M
Combined Cortical and Subcortical Recording and Stimulation as a Circuit-Oriented Treatment for Obsessive-Compulsive DisorderUH3NS100548 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI DOUGHERTY, DARIN D, WIDGE, ALIK S. · 2016 to 2024
$3.2M
Neostriatum in Learning and MemoryR01EY017658 · NEI · MASSACHUSETTS GENERAL HOSPITAL · PI ESKANDAR, EMAD N · 2007 to 2013
$2.7M
Striatal Deep Brain Stimulation for Learning EnhancementR01DA026297 · NIDA · MASSACHUSETTS GENERAL HOSPITAL · PI ESKANDAR, EMAD N · 2008 to 2011
$1.5M
Seizure focus delineation using spontaneous and stimulus evoked EEG featuresK24NS088568 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI CASH, SYDNEY S · 2015 to 2019
$923k
Synchronizing a Fear Regulation Circuit By Temporally Patterned Closed-LoopNeurostimulationR21MH109722 · NIMH · UNIVERSITY OF MINNESOTA · PI WIDGE, ALIK S. · 2016 to 2017
$444k
NEI NIH HHS R01 EY017658NIDA NIH HHS R01 DA026297NIMH NIH HHS P50 MH086400NIMH NIH HHS R01 MH111872NIMH NIH HHS R21 MH109722NINDS NIH HHS K24 NS088568NINDS NIH HHS UH3 NS100548
6 · The paper itself

Abstract

backgroundElectrical neuromodulation via implanted electrodes is used in treating numerous neurological disorders, yet our knowledge of how different brain regions respond to varying stimulation parameters is sparse. OBJECTIVE/HYPOTHESIS: We hypothesized that the neural response to electrical stimulation is both region-specific and non-linearly related to amplitude and frequency.

methodsWe examined evoked neural responses following 400 ms trains of 10-400 Hz electrical stimulation ranging from 0.1 to 10 mA. We stimulated electrodes implanted in cingulate cortex (dorsal anterior cingulate and rostral anterior cingulate) and subcortical regions (nucleus accumbens, amygdala) of non-human primates (NHP, N = 4) and patients with intractable epilepsy (N = 15) being monitored via intracranial electrodes. Recordings were performed in prefrontal, subcortical, and temporal lobe locations.

resultsIn subcortical regions as well as dorsal and rostral anterior cingulate cortex, response waveforms depended non-linearly on frequency (Pearson's linear correlation r < 0.39), but linearly on current (r > 0.58). These relationships between location, and input-output characteristics were similar in homologous brain regions with average Pearson's linear correlation values r > 0.75 between species and linear correlation values between participants r > 0.75 across frequency and current values per brain region. Evoked waveforms could be described by three main principal components (PCs) which allowed us to successfully predict response waveforms across individuals and across frequencies using PC strengths as functions of current and frequency using brain region specific regression models.

conclusionsThese results provide a framework for creation of an atlas of input-output relationships which could be used in the principled selection of stimulation parameters per brain region.

Indexed as

AdultAmygdalaAnimalsBrainBrain MappingDeep Brain StimulationElectrodes, ImplantedFemaleGyrus CinguliHumansMacaca mulattaMaleMiddle AgedNucleus AccumbensPrimatesSpecies SpecificityCingulate cortexCurrentFrequencyIntracranialLocal field potentialNeuromodulation

Identifiers

PMID30904423
PMCPMC6752738
OpenAlexW2921548349

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.