Evidence map›Paper›PMID 30904228›Full record

ArticleClinical nutrition ESPEN2019

Impact of a 12-month Inflammation Management Intervention on the Dietary Inflammatory Index, inflammation, and lipids.

Gabrielle M Turner-McGrievy, Michael D Wirth, Nitin Shivappa, Caroline G Dunn, Anthony Crimarco, Thomas G Hurley, Delia S West, James R Hussey, James R Hébert

2 registry-linked trialsAbstract read
In one paragraph

Article in Clinical nutrition ESPEN, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02382458 nacompletednot on this map

Developing the Dietary Inflammatory Index for Clinical Application

TypeinterventionalSponsorUniversity of South CarolinaRan2015 to 2017Enrolled97ConditionsInflammationArmsNewsletters on cancer prevention and control, Behavioral program to reduce inflammation
NCT03987776 nacompletednot on this map

The Effect of an Anti-Inflammatory Diet on Weight Loss, Body Composition, Cardiometabolic Risk Factors and Immune System Response in Younger Adults

TypeinterventionalSponsorClinical Hospital Center RijekaRan2019 to 2023Enrolled220ConditionsObesityArmsAnti-inflammatory energy-restricted diet, Control energy-restricted diet
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Gabrielle M Turner-McGrievyDepartment of Health Promotion, Education, and Behavior, Arnold School of Public Health, University of South Carolina, 915 Greene Street, Room 529, Columbia, SC 29208, USA. Electronic address: brie@sc.edu.
Michael D WirthDepartment of Epidemiology and Biostatistics, Arnold School of Public Health, USA; Cancer Prevention and Control Program, Arnold School of Public Health, USA; College of Nursing, University of South Carolina, USA; Connecting Health Innovations LLC, USA.
Nitin ShivappaDepartment of Epidemiology and Biostatistics, Arnold School of Public Health, USA; Cancer Prevention and Control Program, Arnold School of Public Health, USA; Connecting Health Innovations LLC, USA.
Caroline G DunnDepartment of Health Promotion, Education, and Behavior, Arnold School of Public Health, University of South Carolina, 915 Greene Street, Room 529, Columbia, SC 29208, USA.
Anthony CrimarcoDepartment of Health Promotion, Education, and Behavior, Arnold School of Public Health, University of South Carolina, 915 Greene Street, Room 529, Columbia, SC 29208, USA.
Thomas G HurleyCancer Prevention and Control Program, Arnold School of Public Health, USA.
Delia S WestDepartment of Exercise Science, Arnold School of Public Health, USA.
James R HusseyDepartment of Epidemiology and Biostatistics, Arnold School of Public Health, USA.
James R HébertDepartment of Epidemiology and Biostatistics, Arnold School of Public Health, USA; Cancer Prevention and Control Program, Arnold School of Public Health, USA; Connecting Health Innovations LLC, USA.
University of South Carolina · USConnecting Health Innovations (United States) · US

Funding

Developing the Dietary Inflammatory Index for Clinical ApplicationR44DK103377 · NIDDK · CONNECTING HEALTH INNOVATIONS, LLC · PI SHIVAPPA, NITIN, WIRTH, MICHAEL DAVID · 2014 to 2016
$1.8M
NIDDK NIH HHS R44 DK103377
6 · The paper itself

Abstract

BACKGROUND AND

aimsThe objective of this study was to assess the feasibility (ability to recruit participants and develop the 12-month intervention), acceptability (retention of participants in the intervention), and impact on systemic inflammation and Dietary Inflammatory Index (DII®) scores over a 12-month DII-based intervention.

methodsAdults were recruited to participate in a self-selection trial (intervention: n = 61, in-person classes; control: n = 34, newsletters). Classes included participatory cooking and dietary recommendations focused on consuming a plant-based diet rich in anti-inflammatory foods (spices, vegetables, etc.). Changes in markers of inflammation, lipids, and DII were analyzed using general linear models with repeated measurements.

resultsAt 3 months, intervention participants had significantly lower DII scores (-2.66 ± 2.44) compared to controls (-0.38 ± 2.56) (p < 0.01); but not at 12 months (P = 0.10). The only biomarker to approach a significant group effect or group-by-time interaction was CRP (P = 0.11 for the group-by-time interaction). CRP decreased by -0.65 mg/L (95%CI = 0.10-1.20, P = 0.02) at 12 months in the intervention group; no significant decrease was seen for the control group. With both groups combined at 3 months, those with the greatest decrease/improvement in DII score (tertile 1) compared with those whose scores increased (tertile 3) had greater reductions in CRP (-1.09 vs. +0.52 mg/L, P = 0.04), total cholesterol (-9.38 vs. +12.02 mg/dL, P = 0.01), and LDL cholesterol (-11.99 vs. +7.16 mg/dL, P = 0.01).

conclusionsAlthough the intervention group had reductions in DII and CRP, main inflammation and lipid outcomes did not differ between groups. Overall, those participants with the largest reduction in DII scores had the largest reductions in CRP and LDL and total cholesterol. Future interventions may need to have more components in place to support maintenance and continued reductions in the DII. CLINICALTRIALS. GOV IDENTIFIER: NCT02382458.

Indexed as

Case-Control StudiesDiet, Fat-RestrictedPatient SelectionBiomarkersFeasibility StudiesFemaleHumansInflammationMaleMiddle AgedBiomarkersDietDietary inflammatory indexInflammationInterventionLipidsSelf-selection trial

Identifiers

PMID30904228
PMCPMC6435295
OpenAlexW2918483475

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.