Evidence map›Paper›PMID 30904077›Full record

ReviewThe Journal of investigative dermatology2019

Research Techniques Made Simple: Profiling the Skin Microbiota.

Max D Grogan, Casey Bartow-McKenney, Laurice Flowers, Simon A B Knight, Aayushi Uberoi, Elizabeth A Grice

Abstract readReview
In one paragraph

Review in The Journal of investigative dermatology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed.

  1. Article
  2. Article
  3. New Personalized Medicine Model for Medication Management.Journal of personalized medicine · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Microbiome dysbiosis and therapeutic restoration in atopic dermatitis.Frontiers in cellular and infection microbiology · 2026
    Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. In the eye of the ophthalmologist: the corneal microbiome in microbial keratitis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024
    Article
  15. Article
  16. The inner elbow skin microbiome containsMicrobiome research reports · 2024
    Article
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Max D GroganDepartment of Dermatology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Casey Bartow-McKenneyDepartment of Dermatology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Laurice FlowersDepartment of Dermatology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Simon A B KnightDepartment of Dermatology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Aayushi UberoiDepartment of Dermatology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Elizabeth A GriceDepartment of Dermatology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA; Department of Microbiology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA. Electronic address: egrice@pennmedicine.upenn.edu.

Funding

Penn Dermatology Research Training ProgramT32AR007465 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI Elizabeth Anne Grice, David Joel Margolis · 1986 to 2026
$9.0M
Study Design and Data AnalysisP30AR069589 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI Elizabeth Anne Grice · 2016 to 2026
$8.6M
Decoding the microbial burden in diabetic foot ulcersR01NR015639 · NINR · UNIVERSITY OF PENNSYLVANIA · PI GRICE, ELIZABETH ANNE · 2015 to 2023
$4.1M
Skin microbiome interactions with complementR01AR066663 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI GRICE, ELIZABETH ANNE · 2015 to 2019
$1.8M
The Microbiome of Impaired Wound HealingR00AR060873 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI GRICE, ELIZABETH ANNE · 2012 to 2014
$730k
NIAMS NIH HHS P30 AR069589NIAMS NIH HHS R00 AR060873NIAMS NIH HHS R01 AR066663NIAMS NIH HHS T32 AR007465NINR NIH HHS R01 NR015639
6 · The paper itself

Abstract

Skin is colonized by microbial communities (microbiota) that participate in immune homeostasis, development and maintenance of barrier function, and protection from pathogens. The past decade has been marked by an increased interest in the skin microbiota and its role in cutaneous health and disease, in part due to advances in next-generation sequencing platforms that enable high-throughput, culture-independent detection of bacteria, fungi, and viruses. Various approaches, including bacterial 16S ribosomal RNA gene sequencing and metagenomic shotgun sequencing, have been applied to profile microbial communities colonizing healthy skin and diseased skin including atopic dermatitis, psoriasis, and acne, among others. Here, we provide an overview of culture-dependent and -independent approaches to profiling the skin microbiota and the types of questions that may be answered by each approach. We additionally highlight important study design considerations, selection of controls, interpretation of results, and limitations and challenges.

Indexed as

BacteriaBiomedical ResearchDermatitisHigh-Throughput Nucleotide SequencingHumansMetagenomeMicrobiotaSequence Analysis, DNASkin

Identifiers

PMID30904077
PMCPMC7439564

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.