Evidence map›Paper›PMID 30903985›Full record

ArticleDrug and alcohol dependence2019

Confirmed marijuana use and lymphocyte count in black people living with HIV.

Larry Keen, Antonio Abbate, Gwenna Blanden, Christen Priddie, F Gerard Moeller, Mobeen Rathore

Abstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug and alcohol dependence, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Larry KeenDepartment of Psychology, Virginia State University, United States. Electronic address: LKeen@vsu.edu.
Antonio AbbateVCU Pauley Heart Center, Virginia Commonwealth University, United States.
Gwenna BlandenDepartment of Psychology, Virginia State University, United States.
Christen PriddieDepartment of Psychology, Virginia State University, United States.
F Gerard MoellerInstitute for Drug and Alcohol Studies, Virginia Commonwealth University, United States.
Mobeen RathoreUniversity of Florida Center for AIDS/HIV Research, Service, and Education University of Florida, United States.

Funding

Research Supplement to Promote Diversity in Health Related ResearchUL1TR002649 · NCATS · VIRGINIA COMMONWEALTH UNIVERSITY · PI MOELLER, FREDERICK GERARD · 2018 to 2022
$19.1M
NCATS NIH HHS UL1 TR002649
6 · The paper itself

Abstract

backgroundMarijuana is a commonly used recreational substance with purported analgesic and mood enhancing properties. Many people living with HIV identify marijuana as a palliative substance. However, through its main psychoactive component, tetrahydrocannabinol (THC), is known to influence the immune system. The effects of marijuana use in people with HIV are still controversial, with very scant literature in Black adults.

methodsThe current study determined the differences in the lymphocyte count, specifically the number cluster differentiation 4 and 8 (CD4+ and CD8+), among patients who urine drug tested negative for THC (n = 70) and those who tested positive for THC (n = 25). The sample included 95 Black people living with HIV, 51% female, with a mean age of 46 ± 11 years. Participants provided a urine sample for substance use testing and a trained researcher extracted clinical data from clinical charts on the day of appointment.

resultsAfter adjusting for demographic and HIV-related covariates, THC-positive patients had significantly higher CD4+ and CD8+ counts than their THC-negative counterparts.

conclusionThese results extend previous HIV-related immunity findings in an underrepresented group, and suggest that THC use does not reduce immune function as measured by CD count. Further research is warranted on the overall effects of THC on immune function in HIV positive patients.

Indexed as

CD4-Positive T-LymphocytesCD8-Positive T-LymphocytesAdultBlack or African AmericanBlack PeopleDronabinolFemaleHIVHIV InfectionsHumansLymphocyte CountMaleMarijuana AbuseMarijuana UseMiddle AgedDronabinolAfrican AmericanCD4+CD8+HIVMarijuanaTHC

Identifiers

PMID30903985
PMCPMC7250156

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.