ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2019
Electrophysiological differences between upper and lower limb movements in the human subthalamic nucleus.
Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 49 citations in OpenAlex.
- Adaptive deep brain stimulation for dynamic gait control in Parkinson's disease: a randomized feasibility trial.Nature medicine · 2026Trial
- Dopamine and the dynamics of subthalamic and leg muscle activities in parkinsonian stepping.Brain : a journal of neurology · 2026Article
- Spatial propagation of movement-related basal ganglia activity predicts parkinsonian motor state.Brain : a journal of neurology · 2026Article
- Lower limb motor effects of DBS neurofeedback in Parkinson's disease assessed through IMU-based UPDRS movement quality metrics.Scientific reports · 2025Article
- Adaptive deep brain stimulation timed to gait phase improves walking in Parkinson's disease.medRxiv : the preprint server for health sciences · 2025Article
- Long-term consistency of aperiodic and periodic physiomarkers in subthalamic local field potentials in Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Differential Beta and Gamma Activity Modulation during Unimanual and Bimanual Motor Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Subthalamic stimulation modulates context-dependent effects of beta bursts during fine motor control.Nature communications · 2024Article
- Clinical neurophysiological interrogation of motor slowing: A critical step towards tuning adaptive deep brain stimulation.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2023Article
- Subthalamic and nigral neurons are differentially modulated during parkinsonian gait.Brain : a journal of neurology · 2023Article
- Spectral Topography of the Subthalamic Nucleus to Inform Next-Generation Deep Brain Stimulation.Movement disorders : official journal of the Movement Disorder Society · 2023Article
- Combining Multimodal Biomarkers to Guide Deep Brain Stimulation Programming in Parkinson Disease.Neuromodulation : journal of the International Neuromodulation Society · 2023Article
- Review
- Cortical and Subthalamic Nucleus Spectral Changes During Limb Movements in Parkinson's Disease Patients with and Without Dystonia.Movement disorders : official journal of the Movement Disorder Society · 2022Article
- Subthalamic high-beta oscillation informs the outcome of deep brain stimulation in patients with Parkinson's disease.Frontiers in human neuroscience · 2022Article
- Towards guided and automated programming of subthalamic area stimulation in Parkinson's disease.Brain communications · 2022Article
- Controlling Clinical States Governed by Different Temporal Dynamics With Closed-Loop Deep Brain Stimulation: A Principled Framework.Frontiers in neuroscience · 2021Article
- Improving Deep Brain Stimulation Electrode PerformanceFrontiers in neuroscience · 2021Article
- Waveform changes with the evolution of beta bursts in the human subthalamic nucleus.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2020Article
- The Cumulative Effect of Transient Synchrony States on Motor Performance in Parkinson's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveFunctional processes in the brain are segregated in both the spatial and spectral domain. Motivated by findings reported at the cortical level in healthy participants we test the hypothesis in the basal ganglia of Parkinson's disease patients that lower frequency beta band activity relates to motor circuits associated with the upper limb and higher beta frequencies with lower limb movements.
methodsWe recorded local field potentials (LFPs) from the subthalamic nucleus using segmented "directional" DBS leads, during which patients performed repetitive upper and lower limb movements. Movement-related spectral changes in the beta and gamma frequency-ranges and their spatial distributions were compared between limbs.
resultsWe found that the beta desynchronization during leg movements is characterised by a strikingly greater involvement of higher beta frequencies (24-31 Hz), regardless of whether this was contralateral or ipsilateral to the limb moved. The spatial distribution of limb-specific movement-related changes was evident at higher gamma frequencies.
conclusionLimb processing in the basal ganglia is differentially organised in the spectral and spatial domain and can be captured by directional DBS leads. SIGNIFICANCE: These findings may help to refine the use of the subthalamic LFPs as a control signal for adaptive DBS and neuroprosthetic devices.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.