Evidence map›Paper›PMID 30903717›Full record

ArticlePediatric diabetes2019

Trends in prevalence of cardiovascular risk factors from 2002 to 2012 among youth early in the course of type 1 and type 2 diabetes. The SEARCH for Diabetes in Youth Study.

Grace Kim, Jasmin Divers, Nora F Fino, Dana Dabelea, Jean M Lawrence, Kristi Reynolds, Ronny A Bell, Elizabeth Mayer-Davis, Tessa Crume, David J Pettitt and 2 more

Abstract read
In one paragraph

Article in Pediatric diabetes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 2 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 1 country.

Grace KimDepartment of Pediatrics, University of Washington, Seattle.ORCID 0000-0002-5115-884X
Jasmin DiversDepartment of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina.
Nora F FinoDepartment of Biostatistical Sciences, Oregon Health and Science University, Portland, Oregon.
Dana DabeleaDepartment of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, Colorado.ORCID 0000-0001-9514-8929
Jean M LawrenceDepartment of Research & Evaluation, Kaiser Permanente Southern CA, Pasadena, California.
Kristi ReynoldsDepartment of Research & Evaluation, Kaiser Permanente Southern CA, Pasadena, California.ORCID 0000-0001-7619-1649
Ronny A BellDepartment of Public Health, East Carolina University, Greenville, North Carolina.
Elizabeth Mayer-DavisDepartment of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.ORCID 0000-0003-3858-0517
Tessa CrumeDepartment of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, Colorado.ORCID 0000-0002-5397-4154
David J PettittSanta Barbara, California.
Catherine PihokerDepartment of Pediatrics, University of Washington, Seattle.ORCID 0000-0001-9074-7770
Lenna LiuDepartment of Pediatrics, University of Washington, Seattle.
University of Washington · USColorado School of Public Health · USKaiser Permanente · USEast Carolina University · USOregon Health & Science University · USUniversity of North Carolina at Chapel Hill · USWake Forest University · US

Funding

Transform Dissemination and Implementation Science in CTSA ProgramsUL1TR002319 · NCATS · UNIVERSITY OF WASHINGTON · PI John K. Amory · 2017 to 2026
$100.0M
Institute of Translational Health SciencesUL1TR000423 · NCATS · UNIVERSITY OF WASHINGTON · PI DISIS, MARY L. · 2012 to 2016
$49.4M
South Carolina Clinical & Translational Research Institute (SCTR)UL1TR001450 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T., FLUME, PATRICK A · 2015 to 2024
$41.1M
LCenter for Clinical and Translational Science and TrainingUL1TR001425 · NCATS · UNIVERSITY OF CINCINNATI · PI HEUBI, JAMES E., KISSELA, BRETT M · 2015 to 2024
$37.5M
Colorado Clinical and Translational Science Institute (UL1)UL1TR000154 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2012 to 2013
$20.4M
Limited Competition for the Continuation of the SEARCH for Diabetes in Youth Cohort Study (UC4)SEARCH for Diabetes in Youth Cohort StudyUC4DK108173 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DAGOSTINO, RALPH B. · 2015 to 2016
$14.8M
UCHSC DIABETES ENDOCRINOLOGY RESEARCH CENTERP30DK057516 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI HUTTON, JOHN C · 2000 to 2010
$14.0M
Cincinnati Center for Clinical and Translational Sciences and TrainingUL1TR000077 · NCATS · UNIVERSITY OF CINCINNATI · PI HEUBI, JAMES E., TSEVAT, JOEL · 2012 to 2014
$9.9M
South Carolina Clinical & Translational Research Institute (SCTR)UL1TR000062 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T. · 2012 to 2014
$9.4M
SEARCH for Diabetes in Youth Coordinating CenterU01DP000250 · DP · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BELL, RONNY A · 2005 to 2009
$4.8M
SEARCH For Diabetes in Youth, Phase 3: Cohort Study-Carolina CenterU18DP002708 · DP · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MAYER-DAVIS, ELIZABETH J · 2010 to 2014
$3.6M
SEARCH for Diabetes in Youth 2: Colorado CenterU01DP000247 · DP · UNIVERSITY OF COLORADO DENVER · PI DABELEA, DANA · 2005 to 2009
$3.6M
ACL HHS 90DP0027ACL HHS U18DP006131ACL HHS U18DP006133ACL HHS U18DP006134ACL HHS U18DP006136ACL HHS U18DP006138ACL HHS U18DP006139CDC HHS 00097CDC HHS 1U18DP002709CDC HHS 1U18DP006131CDC HHS 200-2010-35171CDC HHS DP-05-069CDC HHS DP-10-001CDC HHS U18DP000247-06A1CDC HHS U18DP002708CDC HHS U18DP002710-01CDC HHS U18DP002714CDC HHS U48/CCU419249CDC HHS U48/CCU519239CDC HHS U48/CCU819241-3CDC HHS U48/CCU919219CDC HHS U58/CCU019235-4NCATS NIH HHS UL1 TR000062NCATS NIH HHS UL1 TR000077NCATS NIH HHS UL1 TR000154NCATS NIH HHS UL1 TR000423NCATS NIH HHS UL1 TR001425NCATS NIH HHS UL1 Tr001450NCATS NIH HHS UL1 TR002319NCCDPHP CDC HHS U01 DP000244NCCDPHP CDC HHS U01 DP000246NCCDPHP CDC HHS U01 DP000247NCCDPHP CDC HHS U01 DP000248NCCDPHP CDC HHS U01 DP000250NCCDPHP CDC HHS U01 DP000254NCCDPHP CDC HHS U18 DP002708NCCDPHP CDC HHS U18 DP002709NCCDPHP CDC HHS U18 DP002710NCCDPHP CDC HHS U18 DP002714NCCDPHP CDC HHS U18 DP006131NCCDPHP CDC HHS U18 DP006133NCCDPHP CDC HHS U18 DP006134NCCDPHP CDC HHS U18 DP006136NCCDPHP CDC HHS U18 DP006138NCCDPHP CDC HHS U18 DP006139NIDDK NIH HHS P30 DK057516NIDDK NIH HHS UC4 DK108173NIH HHS 1UC4DK108173NIH HHS P30 DK57516NIH HHS UL1 TR00423
6 · The paper itself

Abstract

backgroundGiven diabetes is an important risk factor for cardiovascular disease (CVD), we examined temporal trends in CVD risk factors by comparing youth recently diagnosed with type 1 diabetes (T1D) and type 2 diabetes (T2D) from 2002 through 2012.

methodsThe SEARCH for Diabetes in Youth Study identified youth with diagnosed T1D (n = 3954) and T2D (n = 706) from 2002 to 2012. CVD risk factors were defined using the modified Adult Treatment Panel III criteria for metabolic syndrome: (a) hypertension; (b) high-density lipoprotein cholesterol ≤40 mg/dL; (c) triglycerides ≥110 mg/dL; and (d) waist circumference (WC) >90th percentile. Prevalence of CVD risk factors, stratified by diagnosis year and diabetes type, was reported. Univariate and multivariate logistic models and Poisson regression were fit to estimate the prevalence trends for CVD risk factors individually and in clusters (≥2 risk factors).

resultsThe prevalence of ≥2 CVD risk factors was higher in youth with T2D than with T1D at each incident year, but the prevalence of ≥2 risk factors did not change across diagnosis years among T1D or T2D participants. The number of CVD risk factors did not change significantly in T1D participants, but increased at an annual rate of 1.38% in T2D participants. The prevalence of hypertension decreased in T1D participants, and high WC increased in T2D participants.

conclusionThe increase in number of CVD risk factors including large WC among youth with T2D suggests a need for early intervention to address these CVD risk factors. Further study is needed to examine longitudinal associations between diabetes and CVD.

Indexed as

AdolescentAge FactorsAge of OnsetCardiovascular DiseasesChildChild, PreschoolDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2Diabetic AngiopathiesDisease ProgressionFemaleHumansIndians, North AmericanMalePrevalenceRisk Factorsabdominal obesitydiabetes mellitusdyslipidemiahypertensionmetabolic syndrome

Identifiers

PMID30903717
PMCPMC6785186
OpenAlexW2955671901

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.