ArticleEuropean journal of immunology2019
Aspergillus fumigatus corneal infection is regulated by chitin synthases and by neutrophil-derived acidic mammalian chitinase.
Article in European journal of immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
- Perforin-2 is dispensable for host defense againstbioRxiv : the preprint server for biology · 2024Article
- Neutrophils in Ocular Diseases.International journal of molecular sciences · 2024Review
- Characterization ofJournal of medical microbiology · 2024Article
- Immune Mechanisms of Filamentous Fungal Keratitis.Cureus · 2024Review
- Aspergillus fumigatus Hypoxia Adaptation Is Critical for the Establishment of Fungal Keratitis.Investigative ophthalmology & visual science · 2024Article
- Immunity to pathogenic fungi in the eye.Seminars in immunology · 2023Review
- Aspergillus fumigatus transcription factor ZfpA regulates hyphal development and alters susceptibility to antifungals and neutrophil killing during infection.PLoS pathogens · 2023Article
- Article
- Chitin Biosynthesis inJournal of fungi (Basel, Switzerland) · 2023Review
- Defense Mechanisms of CottonInternational journal of molecular sciences · 2022Review
- Occupational exposure to gasoline in gasoline station male attendants promotes M1 polarization in macrophages.Environmental science and pollution research international · 2022Article
- Pathogenic Aspergillus and Fusarium as important causes of blinding corneal infections - the role of neutrophils in fungal killing, tissue damage and cytokine production.Current opinion in microbiology · 2021Review
- Isorhamnetin Ameliorates Aspergillus fumigatus Keratitis by Reducing Fungal Load, Inhibiting Pattern-Recognition Receptors and Inflammatory Cytokines.Investigative ophthalmology & visual science · 2021Article
- What Are the Functions of Chitin Deacetylases inFrontiers in cellular and infection microbiology · 2020Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
Abstract
Aspergillus fumigatus is an important cause of pulmonary and systemic infections in immune compromised individuals, and of corneal ulcers and blindness in immune competent patients. To examine the role of chitin synthases in Aspergillus corneal infection, we analyzed Aspergillus mutants of chitin synthase family 1 and family 2, and found that compared with the parent strain, the quadruple mutants from both families were more readily killed by neutrophils in vitro, and that both also exhibited impaired hyphal growth in the cornea. Further, inhibition of chitin synthases using Nikkomycin Z enhanced neutrophil killing in vitro and in vivo in a murine model of A. fumigatus corneal infection. Acidic mammalian chitinase (AMCase) is mostly produced by macrophages in asthmatic lungs; however, we now demonstrate that neutrophils are a major source of AMCase, which inhibits hyphal growth. In A. fumigatus corneal infection, neutrophils are the major source of AMCase, and addition of AMCase inhibitors or adoptive transfer of neutrophils from AMCase
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