ArticleMycopathologia2019
Zinc Oxide Nanoparticles Inhibition of Initial Adhesion and ALS1 and ALS3 Gene Expression in Candida albicans Strains from Urinary Tract Infections.
Article in Mycopathologia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 52 citations in OpenAlex.
- Nanoparticle-based therapeutic platforms for inflammatory disorders of the urinary system: Engineering local delivery, biointerface regulation, and smart responsive therapy.Materials today. Bio · 2026Review
- Effect of subsequent passages on biofilm formation intensity, ALS genes expression, and cell surface hydrophobicity variability in clinical Candida albicans isolates.Scientific reports · 2026Article
- Exploring the Mechanism of Tannic Acid AgainstPathogens (Basel, Switzerland) · 2026Article
- Zinc oxide nanoparticles againstFrontiers in antibiotics · 2026Review
- Urinary catheters: state of the art and future perspectives - a narrative review.Materials today. Bio · 2025Review
- Species-Specific Stress Responses to Selenium Nanoparticles inNanomaterials (Basel, Switzerland) · 2025Article
- Overexpression of efflux pump and biofilm associated genes in itraconazole resistant Candida albicans isolates causing onychomycosis.Scientific reports · 2025Article
- Elucidation of the mechanisms of fluconazole resistance and repurposing treatment options against urinary Candida spp. isolated from hospitalized patients in Alexandria, Egypt.BMC microbiology · 2024Article
- Possible Molecular Targeting of Biofilm-Associated Genes by Nano-Ag in Candida albicans.Applied biochemistry and biotechnology · 2024Article
- Enhanced antimicrobial efficacy of biogenic ZnO nanoparticles through UV-B activation: A novel approach for textile garment.Heliyon · 2024Article
- Global research trends and hotspots on human intestinal fungi and health: a bibliometric visualization study.Frontiers in cellular and infection microbiology · 2024Article
- Antifungal and antibiofilm effects of probioticFrontiers in cellular and infection microbiology · 2024Article
- Nanotechnology-Based Strategies to Combat Multidrug-ResistantPathogens (Basel, Switzerland) · 2023Review
- Molecular association ofFrontiers in cellular and infection microbiology · 2023Review
- Mechanisms of Antifungal Properties of Metal Nanoparticles.Nanomaterials (Basel, Switzerland) · 2022Review
- Characterization of nanomaterials synthesized from Spirulina platensis extract and their potential antifungal activity.PloS one · 2022Article
- Targeted specific inhibition of bacterial andRSC advances · 2021Article
- In Vitro Antifungal Activity of Silver Nanoparticles Biosynthesized with Beech Bark Extract.Plants (Basel, Switzerland) · 2021Article
- Striking Back against Fungal Infections: The Utilization of Nanosystems for Antifungal Strategies.International journal of molecular sciences · 2021Review
- Susceptibility Pattern of Caspofungin-Coated Gold Nanoparticles Against Clinically ImportantAdvanced pharmaceutical bulletin · 2021Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThe aim of this study was to evaluate effects of zinc oxide nanoparticles (ZnO-np) on initiation adhesion and agglutinin-like sequence (ALS) 1 and ALS3 gene expression, which is the first cell surface protein known to be, required for biofilm formation in 125 Candida albicans (C. albicans) from urinary tract infections (UTIs).
methodsIn this descriptive-analytic study, Candida UTIs was cultured from 280 women admitted in hospital Sayad Shirazi, in Northeastern Iran in the 2018 year. 125 (44.62%) of C. albicans strains were identified by phenotypic and genotypic methods. Susceptibility testing C. albicans strains were determined by the disk diffusion method. ZnO-np with 20-40 nm diameters were prepared, there were confirmed by the X-ray diffraction and scanning electron microscope methods.
results115 susceptible C. albicans and 10 fluconazole-resistant C. albicans strain from UTIs were exposed to sub-minimum inhibitory concentration (Sub-MIC) of ZnO-np (range 0.02-18.1 μg/ml). Expression of the ALS1 and ALS3 genes which are affected by adhesion was evaluated by real-time PCR. One-way ANOVA test statistical analysis was performed with SPSS 16.0. The MIC range of ZnO-np was 0.05-296 µg/ml. Sub-MIC concentration ZnO-np initial adhesion inhibition, and significantly reduced ALS1 and ALS3 gene expression was observed in all strains (P < 0.05). The finding indicated that ZnO-np is effective in reduction of ALS1 and ALS3 expression in fluconazole-resistant strains.
conclusionsTherefore, ZnO-np could be a candidate in the elimination of biofilm C. albicans strains from UTIs in medicine, particularly in medical instruments.
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