Evidence map›Paper›PMID 30903526›Full record

ArticleLasers in medical science2019

Topical and intradermal delivery of PpIX precursors for photodynamic therapy with intense pulsed light on porcine skin model.

Michelle Barreto Requena, José Dirceu Vollet Filho, Andrigo Barboza de Nardi, Andre Escobar, Rozana da Rocha Adams, Vanderlei Salvador Bagnato, Priscila Fernanda Campos de Menezes

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Lasers in medical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. EFFICACY OF LOW-LEVEL LASER THERAPY ON FISTULA-IN-ANO TREATMENT.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 3 countries.

Michelle Barreto RequenaSão Carlos Institute of Physics, University of São Paulo (USP), São Carlos, São Paulo, Brazil. requenamichelle@gmail.com.ORCID http://orcid.org/0000-0002-8690-3053
José Dirceu Vollet FilhoSão Carlos Institute of Physics, University of São Paulo (USP), São Carlos, São Paulo, Brazil.
Andrigo Barboza de NardiCollege of Agricultural and Veterinary Sciences, São Paulo State University (UNESP), Jaboticabal, São Paulo, Brazil.
Andre EscobarCollege of Agricultural and Veterinary Sciences, São Paulo State University (UNESP), Jaboticabal, São Paulo, Brazil.
Rozana da Rocha AdamsCollege of Agricultural and Veterinary Sciences, São Paulo State University (UNESP), Jaboticabal, São Paulo, Brazil.
Vanderlei Salvador BagnatoSão Carlos Institute of Physics, University of São Paulo (USP), São Carlos, São Paulo, Brazil.
Priscila Fernanda Campos de MenezesSão Carlos Institute of Physics, University of São Paulo (USP), São Carlos, São Paulo, Brazil.
Universidade de São Paulo · BRUniversidade Estadual Paulista (Unesp) · BR

Funding

Center for Research in Optics and Photonics 2013/07276-1
6 · The paper itself

Abstract

In order to purposely decrease the time of the photodynamic therapy (PDT) sessions, this study evaluated the effects of PDT using topical and intradermal delivery of two protoporphyrin (PpIX) precursors with intense pulsed light (IPL) as irradiation source. This study was performed on porcine skin model, using an IPL commercial device (Intense Pulse Light, HKS801). IPL effect on different administration methods of two PpIX precursors (ALA and MAL) was investigated: a topical cream application and an intradermal application using a needle-free, high-pressure injection system. Fluorescence investigation showed that PpIX distribution by needle-free injection was more homogeneous than that by cream, suggesting that a shorter drug-light interval in PDT protocols is possible. The damage induced by IPL-PDT assessed by histological analysis mostly shows modifications in collagens fibers and inflammation signals, both expected for PDT. This study suggested an alternative protocol for the PDT treatment, possibility half of the incubation time and with just 3 min of irradiation, making the IPL-PDT, even more, promising for the clinical treatment.

Indexed as

Intense Pulsed Light TherapyPhotochemotherapyAdministration, TopicalAnimalsFluorescenceInjections, IntradermalMaleModels, AnimalPhotosensitizing AgentsProtoporphyrinsSkinSwinePhotosensitizing Agentsprotoporphyrin IXProtoporphyrinsAminolevulinic acidIntense pulsed lightMethyl aminolevulinatePhotodynamic therapyPorcine skin

Identifiers

PMID30903526
OpenAlexW2939347272

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.