Evidence map›Paper›PMID 30903388›Full record

ArticleMikrochimica acta2019

An integrated magnetic microfluidic chip for rapid immunodetection of the prostate specific antigen using immunomagnetic beads.

Zhu Feng, Shaotao Zhi, Lei Guo, Yong Zhou, Chong Lei

Abstract read
PubMed Publisher
In one paragraph

Article in Mikrochimica acta, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 32 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Zhu FengKey Laboratory of Thin Film and Microfabrication (Ministry of Education), Department of Micro-Nano Electronics, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Dongchuan Road 800, Shanghai, 200240, China. feng.z@sjtu.edu.cn.ORCID 0000-0002-4305-1700
Shaotao ZhiKey Laboratory of Thin Film and Microfabrication (Ministry of Education), Department of Micro-Nano Electronics, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Dongchuan Road 800, Shanghai, 200240, China.
Lei GuoKey Laboratory of Thin Film and Microfabrication (Ministry of Education), Department of Micro-Nano Electronics, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Dongchuan Road 800, Shanghai, 200240, China.
Yong ZhouKey Laboratory of Thin Film and Microfabrication (Ministry of Education), Department of Micro-Nano Electronics, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Dongchuan Road 800, Shanghai, 200240, China.
Chong LeiKey Laboratory of Thin Film and Microfabrication (Ministry of Education), Department of Micro-Nano Electronics, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Dongchuan Road 800, Shanghai, 200240, China. leiqhd@sjtu.edu.cn.
Shanghai Jiao Tong University · CN

Funding

National Natural Science Foundation of China 61273065National Science and Technology Support Program 2012BAK08B05Support fund of aerospace technology 15GFZ-JJ02-05Support fund of Joint research center for advanced aerospace technology of Shanghai Academy of Spaceflight Technology-Shanghai Jiao Tong University USCAST2015-2Support fund of Shanghai Jiao Tong University AgriX2015005
6 · The paper itself

Abstract

The authors describe an integrated microfluidic chip for immunodetection of the prostate specific antigen (PSA) by using giant magnetoimpedance (GMI) sensor. This chip contains an immunoreaction platform and a biomarker detection system. The immunoreaction platform contains an incubation chamber and a reactive chamber to implement immunological reaction in microfluidics. The system can detect PSA rapidly with ultra-high sensitivity. Both are fabricated by MEMS technology. Immunomagnetic beads (If PSA binds to its antibody (that is labeled with immunomagnetic beads; IMBs) it will be trapped on the surface of self-assembled film. Trapped IMBs generate a stray magnetic field under the magnetization of the external applied magnetic field and can be detected by the GMI sensor. The chip can detect PSA with a detection limit as low as 0.1 ng ∙ mL

Indexed as

Lab-On-A-Chip DevicesAnimalsAntibodiesBiomarkersEquipment DesignHumansImmunoassayImmunomagnetic SeparationLimit of DetectionMiceMicrofluidic Analytical TechniquesProstate-Specific AntigenAntibodiesBiomarkersProstate-Specific AntigenBiomarker detectionBiosensorGiant magnetoimpedanceImmunomagnetic beadsImmunoreaction platformMagnetic sensorMicro-electromechanical systemsMicrofluidic chipPoint-of-care diagnosticsProstate specific antigen

Identifiers

PMID30903388
OpenAlexW2923040624

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.