Evidence map›Paper›PMID 30903333›Full record

ArticleEuropean radiology2019

Proposed achievable levels of dose and impact of dose-reduction systems for thrombectomy in acute ischemic stroke: an international, multicentric, retrospective study in 1096 patients.

Adrien Guenego, Pascal J Mosimann, Vitor Mendes Pereira, Patrick Nicholson, Kevin Zuber, Jean Albert Lotterie, Tomas Dobrocky, David G Marcellus, Jean Marc Olivot, Michel Piotin and 6 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in European radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  4. Direct 3D rotational venography: Insights in optimizing visualization.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Adrien GuenegoInterventional Neuroradiology Department, Hôpital Pierre-Paul Riquet, Toulouse University Hospital, Place du Dr Baylac, TSA 40 031, 31059, Toulouse Cedex 9, France. adrienguenego@gmail.com.ORCID http://orcid.org/0000-0001-7281-1652
Pascal J MosimannInterventional and Diagnostic Neuroradiology, Bern, Switzerland.
Vitor Mendes PereiraInterventional and Diagnostic Neuroradiology, Toronto Western Hospital, Toronto, Canada.
Patrick NicholsonInterventional and Diagnostic Neuroradiology, Toronto Western Hospital, Toronto, Canada.
Kevin ZuberClinical Research Unit, Fondation Ophtalmologique Adolphe de Rothschild, Paris, France.
Jean Albert LotterieStereotaxic Neurosurgery Department, Toulouse University Hospital, Toulouse, France.
Tomas DobrockyInterventional and Diagnostic Neuroradiology, Bern, Switzerland.
David G MarcellusInterventional and Diagnostic Neuroradiology, Stanford Medical Center, Palo Alto, CA, USA.
Jean Marc OlivotVascular Neurology, Stroke Department, Toulouse University Hospital, Toulouse, France.
Michel PiotinInterventional Neuroradiology, Fondation Ophtalmologique Adolphe de Rothschild, Paris, France.
Jan GrallaInterventional and Diagnostic Neuroradiology, Bern, Switzerland.
Robert FahedInterventional Neuroradiology, Fondation Ophtalmologique Adolphe de Rothschild, Paris, France.
Max WintermarkInterventional and Diagnostic Neuroradiology, Stanford Medical Center, Palo Alto, CA, USA.
Jeremy J HeitInterventional and Diagnostic Neuroradiology, Stanford Medical Center, Palo Alto, CA, USA.
Christophe CognardInterventional Neuroradiology Department, Hôpital Pierre-Paul Riquet, Toulouse University Hospital, Place du Dr Baylac, TSA 40 031, 31059, Toulouse Cedex 9, France.
RADON Investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInternational dose reference levels are lacking for mechanical thrombectomy in acute ischemic stroke patients with large vessel occlusions. We studied whether radiation dose-reduction systems (RDS) could effectively reduce exposure and propose achievable levels. MATERIALS AND

methodsWe retrospectively included consecutive patients treated with thrombectomy on a biplane angiography system (BP) in five international, high-volume centers between January 2014 and May 2017. Institutional Review Board approvals were obtained. Technical, procedural, and clinical characteristics were assessed. Efficacy, safety, radiation dose, and contrast load were compared between angiography systems with and without RDS. Multivariate analyses were adjusted according to Bonferroni's correction. Proposed international achievable cutoff levels were set at the 75th percentile.

resultsOut of the 1096 thrombectomized patients, 520 (47%) were treated on a BP equipped with RDS. After multivariate analysis, RDS significantly reduced dose-area product (DAP) (91 vs 140 Gy cm

conclusionRadiation dose-reduction systems can reduce DAP and air kerma by a third and a half, respectively, without affecting thrombectomy efficacy or safety. The respective thresholds of 148 Gy cm KEY POINTS: • Internationally validated achievable levels may help caregivers and health authorities better assess and reduce radiation exposure of both ischemic stroke patients and treating staff during thrombectomy procedures. • Radiation dose-reduction systems can reduce DAP and air kerma by a third and a half, respectively, without affecting thrombectomy efficacy or safety in the setting of acute ischemic stroke due to large vessel occlusion.

Indexed as

Acute DiseaseAdolescentAdultAgedAged, 80 and overBrain IschemiaCarotid Artery, InternalFemaleFluoroscopyHumansIschemiaMaleMiddle AgedRadiation DosageRadiation ExposureRadiation InjuriesPatient safetyStrokeThrombectomy

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.