ReviewCurrent allergy and asthma reports2019
Evaluating Penicillin Allergies Without Skin Testing.
Review in Current allergy and asthma reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04408508 (Safety and Efficacy of an Oral Penicillin Challenge in Low Risk Hospitalized Patients), which is not on this map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Safety and Efficacy of an Oral Penicillin Challenge in Low Risk Hospitalized Patients
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 92 citations in OpenAlex.
- Sexually Transmitted Infections Treatment Guidelines, 2021.MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports · 2021Guideline
- Randomized Multicenter Trial for the Validation of an Easy-to-Administer Algorithm to Define Penicillin Allergy Status in Sexually Transmitted Infection Clinic Outpatients.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024Trial
- Proactive Penicillin Allergy Delabeling: Lessons Learned From a Quality Improvement Project.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2025Article
- Carbon-Supported Nanocomposite Synthesis, Characterization, and Application as an Efficient Adsorbent for Ciprofloxacin and Amoxicillin.ACS omega · 2024Article
- Resource utilization and cost assessment of a proactive penicillin allergy de-labeling program for low-risk inpatients.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2024Article
- Article
- Risk Stratification of Penicillin Allergy Labeled Children: A Cross-Sectional Study from Jordan.Therapeutics and clinical risk management · 2024Article
- Don't we overestimate drug allergies in children?International journal of occupational medicine and environmental health · 2023Article
- Penicillin de-labelling in vancouver, British Columbia, Canada: comparison of approaches, outcomes and future directions.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2023Article
- Management of the Pregnant Patient with Beta-Lactam Allergy.Current allergy and asthma reports · 2023Review
- Does a Reported Penicillin Allergy Affect Outcomes Following Elective Posterior Lumbar Fusions?International journal of spine surgery · 2022Article
- Standards for practical intravenous rapid drug desensitization & delabeling: A WAO committee statement.The World Allergy Organization journal · 2022Review
- Penilloic acid is the chief culprit involved in non-IgE mediated, immediate penicillin-induced hypersensitivity reactions in mice.Frontiers in pharmacology · 2022Article
- Tools to improve the diagnosis and management of T-cell mediated adverse drug reactions.Frontiers in medicine · 2022Review
- De-labelling penicillin allergy in acutely hospitalized patients: a pilot study.BMC infectious diseases · 2021Article
- The Penicillin Allergy Delabeling Program: A Multicenter Whole-of-Hospital Health Services Intervention and Comparative Effectiveness Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Penicillin Allergy Testing Is Cost-Saving: An Economic Evaluation Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Safety and efficacy of de-labelling penicillin allergy in adults using direct oral challenge: a systematic review.JAC-antimicrobial resistance · 2021Review
- Penicillin Allergy Assessment in Pregnancy: Safety and Impact on Antibiotic Use.The journal of allergy and clinical immunology. In practice · 2021Article
- Penicillin Allergy Delabeling Can Decrease Antibiotic Resistance, Reduce Costs, and Optimize Patient Outcomes.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewAn unconfirmed penicillin allergy is known to confer significant risk to patients. Only a small minority of patients labeled with penicillin allergy will be confirmed to be hypersensitive with the current reference standard test, an oral amoxicillin therapeutic dose challenge. Skin testing has been recommended prior to oral challenges to reduce the risk of severe acute challenge reactions. The rate of severe acute anaphylactic reactions with oral amoxicillin is currently extremely low. Unfortunately, penicillin skin testing, as commonly performed, has a high rate of false positive results. RECENT
findingsEncouraging skin testing in all individuals with an unconfirmed penicillin allergy, prior to a confirmatory oral challenge, would be technically difficult, make testing all individuals with an unconfirmed penicillin allergy very unlikely, and ultimately increase the risk to patients because of suboptimal antibiotic use. Most patients, who are appropriate candidates for a direct oral amoxicillin challenge, to confirm current penicillin tolerance, can be safely identified by their clinical histories. Higher risk individuals, those with a history of anaphylaxis or other acute onset potentially IgE-mediated reaction such as hives within 6 h of the first dose of the last course of a penicillin, may benefit from properly performed puncture and intradermal skin testing, using commercially available penicilloyl-polylysine, prior to an oral challenge, if skin test negative. Direct oral amoxicillin challenges in low-risk individuals are well accepted by patients and a safe and effective part of penicillin allergy delabeling.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.