Evidence map›Paper›PMID 30903276›Full record

Trial reportSurgical endoscopy2020

Intraoperative angiography with indocyanine green to assess anastomosis perfusion in patients undergoing laparoscopic colorectal resection: results of a multicenter randomized controlled trial.

Paola De Nardi, Ugo Elmore, Giulia Maggi, Riccardo Maggiore, Luigi Boni, Elisa Cassinotti, Uberto Fumagalli, Marco Gardani, Stefano De Pascale, Paolo Parise and 2 more

3 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Surgical endoscopy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 172 papers, 30 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
172citing papers in PubMed, 30 pooled it
14.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02662946 nacompletednot on this map

Evaluation of Intestinal Vascolarization by Intraoperative Angiography With Indocianine Green During Laparoscopi Rectal Resection or Left Colectomy: Predictive Value on Anastomotic Leak.

TypeinterventionalSponsorScientific Institute San RaffaeleRan2016 to 2017Enrolled208ConditionsRectal Disease, Sigmoid DiseaseArmsICG- angiography, No angiography
NCT05411783 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Low Tie Versus High Tie of the Inferior Mesenteric Vein During Colorectal Cancer Surgery: A Randomized Clinical Trial. LOTHVEIN Study

TypeinterventionalSponsorSan Carlo di Nancy HospitalRan2022 to 2023Enrolled84ConditionsAnastomotic Leak, Anastomotic Leak Large Intestine, Anastomotic Leak Rectum, Colon CancerArmsLow tie of IMV
NCT07720505 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

COLOFLOW: Laser Speckle Contrast Imaging Versus Near-infrared Fluorescence Imaging With Indocyanine Green

TypeobservationalSponsorLeiden University Medical CenterRan2026 to 2027Enrolled30ConditionsLeakage, Anastomotic, Colon Cancer, Colon Anastomosis, Colon and Rectal CancerArmsLaser Speckle Contrast Imaging
3 · Its place in the literature

Who cites it

172 citing papers in PubMed, 30 syntheses or guidelines pooled it, 298 citations in OpenAlex.

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  19. Intraluminal Anastomotic Assessment Using Indocyanine Green Near-Infrared Imaging for Left-Sided Colonic and Rectal Resections: a Systematic Review.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2023
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112 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Paola De NardiDepartment of Gastrointestinal Surgery, San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy. denardi.paola@hsr.it.ORCID 0000-0002-9337-6765
Ugo ElmoreDepartment of Gastrointestinal Surgery, San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy.
Giulia MaggiDepartment of Gastrointestinal Surgery, San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy.
Riccardo MaggioreDepartment of Gastrointestinal Surgery, San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy.
Luigi BoniDepartment of Surgery, IRCCS Ca' Granda, Ospedale Maggiore Policlinico, University of Milan, Milan, Italy.
Elisa CassinottiDepartment of Surgery, IRCCS Ca' Granda, Ospedale Maggiore Policlinico, University of Milan, Milan, Italy.
Uberto FumagalliChirurgia Generale 2, ASST Spedali Civili, Brescia, Italy.
Marco GardaniChirurgia Generale 2, ASST Spedali Civili, Brescia, Italy.
Stefano De PascaleChirurgia Generale 2, ASST Spedali Civili, Brescia, Italy.
Paolo PariseDepartment of Gastrointestinal Surgery, San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy.
Andrea VignaliDepartment of Gastrointestinal Surgery, San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy.
Riccardo RosatiDepartment of Gastrointestinal Surgery, San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy.
San Raffaele University of Rome · ITAzienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · ITUniversity of Milan · ITVita-Salute San Raffaele University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInsufficient vascular supply is one of the main causes of anastomotic leak in colorectal surgery. Intraoperative indocyanine-green (ICG) angiography has been shown to provide information on tissue perfusion, identifying a well-perfused location for colonic and rectal transections, and thus possibly reducing the leak rate. Aim of this study was to evaluate the usefulness of intraoperative assessment of anastomotic perfusion using ICG angiography in patients undergoing left-sided colon or rectal resection with colorectal anastomosis.

methodsThis randomized trial involved 252 patients undergoing laparoscopic left-sided colon and rectal resection randomized 1:1 to intraoperative ICG or to subjective visual evaluation of the bowel perfusion without ICG. The primary aim was to assess whether ICG angiography could lead to a reduction in anastomotic leak rate. Secondary outcomes were possible changes in the surgical strategy and postoperative morbidity.

resultsAfter randomization, 12 patients were excluded. Accordingly, 240 patients were included in the analysis; 118 were in the study group, and 122 in the control group. ICG angiography showed insufficient perfusion of the colic stump, which led to extended bowel resection in 13 cases (11%). An anastomotic leak developed in 11 patients (9%) in the control group and in 6 patients (5%) in the study group (p = n.s.).

conclusionsIntraoperative ICG fluorescent angiography can effectively assess vascularization of the colic stump and anastomosis in patients undergoing colorectal resection. This method led to further proximal bowel resection in 13 cases, however, there was no statistically significant reduction of anastomotic leak rate in the ICG arm. CLINICAL TRIAL: ClinicalTrials.gov NCT02662946.

Indexed as

Anastomosis, SurgicalAnastomotic LeakColectomyLaparoscopyColonColorectal NeoplasmsColoring AgentsFemaleFluorescein AngiographyHumansIndocyanine GreenIntraoperative CareMaleMiddle AgedTreatment OutcomeColoring AgentsIndocyanine GreenAnastomosis perfusionAnastomotic leakColorectal resectionIntraoperative indocyanine-green angiography

Identifiers

PMID30903276
OpenAlexW2940857081

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.