ArticleEuropean archives of psychiatry and clinical neuroscience2020
The neural correlates of low social integration as a risk factor for suicide.
Article in European archives of psychiatry and clinical neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Neural mechanisms of suicide thoughts and behaviors in major depressive disorder: abnormal regional brain activity and its functional connectivity.BMC psychiatry · 2025Pooled it
- Biological research on mental pain, social pain and other pains not primarily felt in the body: methodological systematic review.The British journal of psychiatry : the journal of mental science · 2025Pooled it
- Targeting Psychological Pain After a Suicide Attempt: Scoping Review and Intervention Protocol.Journal of clinical medicine · 2026Review
- Comment on "Perception of social inclusion/exclusion and response inhibition in adolescents with past suicide attempt: a multidomain task-based fMRI study." by Gifuni et al.Molecular psychiatry · 2025Article
- Social problem-solving, interpersonal stress, exclusion, and empathy in suicide risk.Clinical psychology : a publication of the Division of Clinical Psychology of the American Psychological Association · 2024Article
- Neuroimaging alterations of the suicidal brain and its relevance to practice: an updated review of MRI studies.Frontiers in psychiatry · 2023Review
- Synergistic effect of chronic pain and nonsuicidal self-harm on pain sensitivity.European archives of psychiatry and clinical neuroscience · 2022Article
- My Fear Is Not, and Never Will Be, Your Fear: On Emotions and Feelings in Animals.Affective science · 2022Article
- Perceived burdensomeness and neural responses to ostracism in the Cyberball task.Journal of psychiatric research · 2020Article
- Brain responses to social feedback in internalizing disorders: A comprehensive review.Neuroscience and biobehavioral reviews · 2020Review
- "Nothing Hurts Less Than Being Dead": Psychological Pain in Case Descriptions of Psychiatric Euthanasia and Assisted Suicide from the Netherlands: « Rien ne fait moins mal qu'être mort »: La douleur psychologique dans les descriptions de cas d'euthanasie et de suicide assisté psychiatrique aux Pays-Bas.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2020Article
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Authors and funding
6 authors.
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Abstract
Low social integration is commonly described in acutely suicidal individuals. Neural mechanisms underlying low social integration are poorly understood in depressed and suicidal patients. We sought to characterize the neural response to low social integration in acutely suicidal patients. Adult depressed patients within 3 days of a suicide attempt (n = 10), depressed patients with suicidal ideation (n = 9), non-suicidal depressed patients (n = 15), and healthy controls (N = 18) were administered the Cyberball Game while undergoing functional magnetic resonance imaging. We used complementary functional connectivity and region of interest data analysis approaches. There were no group differences in functional connectivity within neural network involving the pain matrix, nor in insula neural activity or the insula during either social inclusion. Superior anterior insula activity exhibited an inverted U-shaped curve across the suicide risk spectrum during social inclusion. Superior insula activity during social inclusion correlated with depression severity and psychological pain. Dorsal anterior cingulate cortex activity during social exclusion correlated with physical pain severity. Neural responses in the anterior insula significantly correlated with depression severity and with psychological pain during social inclusion, whereas dACC activity significantly correlated with physical pain during social exclusion. Recent suicidal behavior seems associated with a distinct neural response to social exclusion independently of presence of depression or suicidal thoughts.
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