Evidence map›Paper›PMID 30903265›Full record

ArticleEuropean biophysics journal : EBJ2019

Slow relaxation during and after perturbation of bistable kinetics of gene expression.

Vladimir P Zhdanov

Abstract read
PubMed Publisher
In one paragraph

Article in European biophysics journal : EBJ, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Vladimir P ZhdanovSection of Biological Physics, Department of Physics, Chalmers University of Technology, Göteborg, Sweden. zhdanov@chalmers.se.
Chalmers University of Technology · SE

Funding

Russian Academy of Sciences and Federal Agency for Scientific Organizations 0303-2016-0001Swedish Foundation for Strategic Research IRC15-0065
6 · The paper itself

Abstract

After a short perturbation of a bistable genetic network, it returns to its initial steady state or transits to another steady state. The time scale characterizing such transient regimes can be appreciably longer compared to those of the degradation of the perturbed mRNAs and proteins. The author shows in detail the specifics of this slowdown of the transient kinetics using mean-field kinetic equations and Monte Carlo simulations. Attention is focused on nanocarrier-mediated delivery and release of short non-coding RNA (e.g., miRNA or siRNA) into cells with subsequent suppression of the populations of the targeted mRNA and corresponding protein.

Indexed as

Gene Regulatory NetworksMonte Carlo MethodKineticsMicroRNAsModels, GeneticRNA, MessengerRNA, Small InterferingMicroRNAsRNA, MessengerRNA, Small InterferingBistabilityDrug deliveryGene expressionMean-field kinetic equationsMonte Carlo simulationsTransient kinetics

Identifiers

PMID30903265
OpenAlexW2923114352

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.