Evidence map›Paper›PMID 30903210›Full record

ArticlePsychopharmacology2019

Effects of combined escitalopram and aripiprazole in rats: role of the 5-HT

Thomas Lapointe, Roger Hudson, Stephen Daniels, Brett Melanson, Yan Zhou, Francesco Leri

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in Psychopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Thomas LapointeDepartment of Psychology, Neuroscience Specialization, University of Guelph, Guelph, N1G 2W1, ON, Canada.
Roger HudsonDepartment of Psychology, Neuroscience Specialization, University of Guelph, Guelph, N1G 2W1, ON, Canada.
Stephen DanielsDepartment of Psychology, Neuroscience Specialization, University of Guelph, Guelph, N1G 2W1, ON, Canada.
Brett MelansonDepartment of Psychology, Neuroscience Specialization, University of Guelph, Guelph, N1G 2W1, ON, Canada.
Yan ZhouLaboratory of Addictive Diseases, Rockefeller University, New York, NY, USA.
Francesco LeriDepartment of Psychology, Neuroscience Specialization, University of Guelph, Guelph, N1G 2W1, ON, Canada. fleri@uoguelph.ca.ORCID http://orcid.org/0000-0003-2700-0812
University of Guelph · CARockefeller University · US

Funding

Ontario Brain Institute CAN-BIND
6 · The paper itself

Abstract

rationalePre-clinical and clinical studies have suggested that the antidepressant efficacy of escitalopram (ESC) can be augmented by co-administration of aripiprazole (ARI).

objectiveTo establish if the effects of ESC + ARI can be altered by modulating the 5-HT

methodsSprague-Dawley male rats received ESC + ARI (10 and 2 mg/kg/day, respectively, via osmotic or by cumulative injections), as well as the 5-HT

resultsWAY generally synergized, while DPAT antagonized, the effect of ESC + ARI on motor activity. All groups showed significantly lower 5-HT

conclusionsTaken together, these results in rats indicate that the 5-HT

Indexed as

8-Hydroxy-2-(di-n-propylamino)tetralinAnimalsAntidepressive AgentsAripiprazoleCitalopramHippocampusLocomotionMaleRatsRats, Sprague-DawleyReceptor, Serotonin, 5-HT1ASelective Serotonin Reuptake InhibitorsSerotonin 5-HT1 Receptor AgonistsSerotonin 5-HT1 Receptor AntagonistsSwimming8-Hydroxy-2-(di-n-propylamino)tetralinAntidepressive AgentsAripiprazoleCitalopramReceptor, Serotonin, 5-HT1ASelective Serotonin Reuptake InhibitorsSerotonin 5-HT1 Receptor AgonistsSerotonin 5-HT1 Receptor Antagonists5-HT1a receptorAntidepressantAripiprazoleAugmentationDepressionEscitalopramForced swimmRNAPsychomotorSSRI

Identifiers

PMID30903210
OpenAlexW2924250095

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.