Evidence map›Paper›PMID 30903206›Full record

ArticleExperimental brain research2019

Modeling the effects of medial olivocochlear efferent stimulation at the level of the inferior colliculus.

T J M Kwan, M S A Zilany, E Davies-Venn, Ahmad Khairi Abdul Wahab

Abstract read
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Article in Experimental brain research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

T J M KwanDepartment of Biomedical Engineering, Faculty of Engineering, University of Malaya, 50603, Kuala Lumpur, Malaysia.
M S A ZilanyElectrical and Computer Engineering Program, Texas A&M University at Qatar, Education City, Doha, 23874, Qatar.
E Davies-VennDepartment of Speech-Language-Hearing Sciences, University of Minnesota, 164 Pillsbury Drive SE, Minneapolis, MN, 55455, USA.
Ahmad Khairi Abdul WahabDepartment of Biomedical Engineering, Faculty of Engineering, University of Malaya, 50603, Kuala Lumpur, Malaysia. khairi@um.edu.my.

Funding

Institut Pengurusan dan Pemantauan Penyelidikan, Universiti Malaya RP006H-13ICTInstitut Pengurusan dan Pemantauan Penyelidikan, Universiti Malaya RP016B-13AETResearch University Grant (RU Faculty) GPF039A-2018
6 · The paper itself

Abstract

Various studies on medial olivocochlear (MOC) efferents have implicated it in multiple roles in the auditory system (e.g., dynamic range adaptation, masking reduction, and selective attention). This study presents a systematic simulation of inferior colliculus (IC) responses with and without electrical stimulation of the MOC. Phenomenological models of the responses of auditory nerve (AN) fibers and IC neurons were used to this end. The simulated responses were highly consistent with physiological data (replicated 3 of the 4 known rate-level responses all MOC effects-shifts, high stimulus level reduction and enhancement). Complex MOC efferent effects which were previously thought to require integration from different characteristic frequency (CF) neurons were simulated using the same frequency inhibition excitation circuitry. MOC-induced enhancing effects were found only in neurons with a CF range from 750 Hz to 2 kHz. This limited effect is indicative of the role of MOC activation on the AN responses at the stimulus offset.

Indexed as

Models, TheoreticalCochleaCochlear NerveEfferent PathwaysElectric StimulationHumansInferior ColliculiSuperior Olivary ComplexAuditory nerve modelComputational modelingEfferentICMOC

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.