ArticleGenome biology and evolution2019
Comparative Genomics Reveals the Genetic Mechanisms of Musk Secretion and Adaptive Immunity in Chinese Forest Musk Deer.
Article in Genome biology and evolution, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Stage-Specific Dynamic of Gut Microbiota Across the Musk-Secretion Cycle in Forest Musk Deer (Microorganisms · 2026Article
- Article
- Fecal steroids, short-chain fatty acids, and microbiota in high- versus low-yielding forest musk deer.AMB Express · 2025Article
- Analysis and comparison of blood metabolome of forest musk deer in musk secretion and non-secretion periods.Scientific reports · 2024Article
- Comparative Analyses Reveal the Genetic Mechanism of Ambergris Production in the Sperm Whale Based on the Chromosome-Level Genome.Animals : an open access journal from MDPI · 2023Article
- Integrated multi-omics analysis reveals insights into Chinese forest musk deer (Frontiers in cell and developmental biology · 2023Article
- Genomic insight into the nocturnal adaptation of the black-crowned night heron (Nycticorax nycticorax).BMC genomics · 2022Article
- Comparative analysis of gut microbial composition and potential functions in captive forest and alpine musk deer.Applied microbiology and biotechnology · 2022Article
- Effect of probiotics on diversity and function of gut microbiota in Moschus berezovskii.Archives of microbiology · 2021Article
- Study of compositions of musks in different types secreted by forest musk deer (Moschus berezovskii).PloS one · 2021Article
- Genome-Wide Analysis of Nubian Ibex Reveals Candidate Positively Selected Genes That Contribute to Its Adaptation to the Desert Environment.Animals : an open access journal from MDPI · 2020Article
- Whole-genome sequencing of wild Siberian musk deer (Moschus moschiferus) provides insights into its genetic features.BMC genomics · 2020Article
- Genomic Identification and Expression Analysis of the Cathelicidin Gene Family of the Forest Musk Deer.Animals : an open access journal from MDPI · 2019Article
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Authors and funding
19 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Chinese forest musk deer (Moschus berezovskii; FMD) is an artiodactyl mammal and is both economically valuable and highly endangered. To investigate the genetic mechanisms of musk secretion and adaptive immunity in FMD, we compared its genome to nine other artiodactyl genomes. Comparative genomics demonstrated that eight positively selected genes (PSGs) in FMD were annotated in three KEGG pathways that were related to metabolic and synthetic activity of musk, similar to previous transcriptome studies. Functional enrichment analysis indicated that many PSGs were involved in the regulation of immune system processes, implying important reorganization of the immune system in FMD. FMD-specific missense mutations were found in two PSGs (MHC class II antigen DRA and ADA) that were classified as deleterious by PolyPhen-2, possibly contributing to immune adaptation to infectious diseases. Functional assessment showed that the FMD-specific mutation enhanced the ADA activity, which was likely to strengthen the immune defense against pathogenic invasion. Single nucleotide polymorphism-based inference showed the recent demographic trajectory for FMD. Our data and findings provide valuable genomic resources not only for studying the genetic mechanisms of musk secretion and adaptive immunity, but also for facilitating more effective management of the captive breeding programs for this endangered species.
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