ArticleNature protocols2019
Synthetic chemistry in water: applications to peptide synthesis and nitro-group reductions.
Article in Nature protocols, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 51 citations in OpenAlex.
- Nanoassembly-enabled aqueous solid-phase peptide synthesis (ASPPS): a practical DMF-free approach based on the Fmoc strategy.RSC advances · 2026Article
- Challenges and Achievements of Peptide Synthesis in Aqueous and Micellar Media.Chembiochem : a European journal of chemical biology · 2025Review
- Chalcone Synthesis by Green Claisen-Schmidt Reaction in Cationic and Nonionic Micellar Media.The Journal of organic chemistry · 2025Article
- Chemoenzymatic Synthesis of Poly-l-lysine via Esterification with Alcohol in One-Pot.ACS polymers Au · 2025Article
- Article
- Process Mass Intensity (PMI): A Holistic Analysis of Current Peptide Manufacturing Processes Informs Sustainability in Peptide Synthesis.The Journal of organic chemistry · 2024Review
- A sustainable, efficient, and potentially cost-effective approach to the antimalarial drug candidate MMV688533.Chemical science · 2023Article
- Direct formation of amide/peptide bonds from carboxylic acids: no traditional coupling reagents, 1-pot, and green.Chemical science · 2023Article
- Coupling photocatalytic water oxidation with reductive transformations of organic molecules.Nature communications · 2022Article
- Chemoenzymatic Polymerization of l-Serine Ethyl Ester in Aqueous Media without Side-Group Protection.ACS polymers Au · 2022Article
- On-DNA Transfer Hydrogenolysis and Hydrogenation for the Synthesis of DNA-Encoded Chemical Libraries.Angewandte Chemie (Weinheim an der Bergstrasse, Germany) · 2022Article
- On-DNA Transfer Hydrogenolysis and Hydrogenation for the Synthesis of DNA-Encoded Chemical Libraries.Angewandte Chemie (International ed. in English) · 2022Article
- Sustainable Peptide Synthesis Enabled by a Transient Protecting Group.Angewandte Chemie (International ed. in English) · 2020Article
- Catalytic direct amidations in tert-butyl acetate using B(OCHOrganic & biomolecular chemistry · 2019Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Amide bond formation and aromatic/heteroaromatic nitro-group reductions represent two of the most commonly used transformations in organic synthesis. Unfortunately, such processes can be especially wasteful and hence environmentally harmful, and may present safety hazards as well, given the reaction conditions involved. The two protocols herein describe alternative technologies that offer solutions to these issues. Polypeptides can now be made in water at ambient temperatures using small amounts of the designer surfactant TPGS-750-M, thereby eliminating the use of organic solvents as the reaction medium. Likewise, a safe, inexpensive and efficient procedure is outlined for nitro-group reductions, using industrial iron in the form of carbonyl iron powder (CIP), an inexpensive item of commerce. The peptide synthesis will typically take, overall, 3-4 h for a simple coupling and 8 h for a two-step deprotection/coupling process. The workup usually consists of a simple extraction and acidic/basic aqueous washings. The nitro reduction procedure will typically take 6-8 h to complete, including setup, reaction time and workup.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.