Evidence map›Paper›PMID 30903100›Full record

ArticleThe Journal of antibiotics2019

Effect of C-2 substitution on the stability of non-traditional cephalosporins in mouse plasma.

Matthew Zimmerman, Stacey L McDonald, Hsin-Pin Ho-Liang, Patrick Porubsky, Quyen Nguyen, Cameron W Pharr, Andrew J Perkowski, Robert Smith, Frank J Schoenen, Ben S Gold and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of antibiotics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Matthew ZimmermanPublic Health Research Institute, New Jersey Medical School, Rutgers, the State University of New Jersey, Newark, NJ, 07013, USA.
Stacey L McDonaldDivision of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Hsin-Pin Ho-LiangPublic Health Research Institute, New Jersey Medical School, Rutgers, the State University of New Jersey, Newark, NJ, 07013, USA.
Patrick PorubskySpecialized Chemistry Center, University of Kansas, Lawrence, KS, 66045, USA.
Quyen NguyenDivision of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Cameron W PharrDivision of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Andrew J PerkowskiDivision of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Robert SmithSpecialized Chemistry Center, University of Kansas, Lawrence, KS, 66045, USA.
Frank J SchoenenSpecialized Chemistry Center, University of Kansas, Lawrence, KS, 66045, USA.
Ben S GoldDepartment of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, 10065, USA.
David ZhangDepartment of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, 10065, USA.
Carl F NathanDepartment of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, 10065, USA.
Véronique DartoisPublic Health Research Institute, New Jersey Medical School, Rutgers, the State University of New Jersey, Newark, NJ, 07013, USA. veronique.dartois@rutgers.edu.
Jeffrey AubéDivision of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. jaube@unc.edu.ORCID http://orcid.org/0000-0003-1049-5767
University of North Carolina at Chapel Hill · USCornell University · USRutgers, The State University of New Jersey · USUniversity of Kansas · US

Funding

Viable but Nonculturable MtbU19AI111143 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI GLICKMAN, MICHAEL S, NATHAN, CARL FRANCIS · 2014 to 2020
$48.6M
University of Kansas Specialized Chemistry CenterU54HG005031 · NHGRI · UNIVERSITY OF KANSAS LAWRENCE · PI AUBE, JEFFREY · 2008 to 2013
$21.5M
A QTRAP 6500 LC-MS/MS System from SCIEX for high accuracy drug content analysisS10OD023524 · OD · RBHS-NEW JERSEY MEDICAL SCHOOL · PI DARTOIS, VERONIQUE · 2017 to 2017
$526k
NHGRI NIH HHS U54 HG005031NIAID NIH HHS U19 AI111143NIH HHS S10 OD023524
6 · The paper itself

Abstract

A systematic study of the stability of a set of cephalosporins in mouse plasma reveals that cephalosporins lacking an acidic moiety at C-2 may be vulnerable to β-lactam cleavage in mouse plasma.

Indexed as

AnimalsAnti-Bacterial AgentsCephalosporinsMiceMolecular StructureStructure-Activity RelationshipAnti-Bacterial AgentsCephalosporins

Identifiers

PMID30903100
PMCPMC7255492
OpenAlexW2923938402

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.