ArticleNature communications2019
Aedes mosquitoes acquire and transmit Zika virus by breeding in contaminated aquatic environments.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Larvicidal activity ofParasite epidemiology and control · 2026Article
- Modelling, analysis and optimal control of Zika virus transmission dynamics based on sterile insect technique.Infectious Disease Modelling · 2026Article
- Zika virus and the fetal-maternal interface: deciphering the mechanisms of placental infection and implications for pregnancy outcomes.Emerging microbes & infections · 2025Review
- Insights on the sex determination, vector capacity and ecological biology from a chromosomal level genome of vector mosquito, Armigeres subulbatus.Infectious diseases of poverty · 2025Article
- Sheep serve as amplifying hosts of Japanese encephalitis virus, increasing the risk of human infection.Science advances · 2025Article
- Zika virus transmission in Aedes aegypti: A systematic study on the ability of mosquitoes to transmit the virus horizontally and vertically.Virologica Sinica · 2025Article
- Natural fatal infection of Tembusu virus in bottlenose dolphins in Thailand.Scientific reports · 2025Article
- Intrauterine Zika Virus Infection: An Overview of the Current Findings.Journal of personalized medicine · 2025Review
- Assessment of flavivirus RNA stability and infectivity in various water environments.Tropical medicine and health · 2025Article
- An Overview of Zika Virus and Zika Virus Induced Neuropathies.International journal of molecular sciences · 2024Review
- West Nile virus can be transmitted within mosquito populations through infectious mosquito excreta.iScience · 2024Article
- Zika virus tropism and pathogenesis: understanding clinical impacts and transmission dynamics.Virology journal · 2024Review
- Multi-omics analysis of antiviral interactions of Elizabethkingia anophelis and Zika virus.Scientific reports · 2024Article
- Transmission dynamics of Zika virus with multiple infection routes and a case study in Brazil.Scientific reports · 2024Article
- Biological determinants perpetuating the transmission dynamics of mosquito-borne flaviviruses.Emerging microbes & infections · 2023Review
- Identification of risk areas for arboviruses transmitted byOne health (Amsterdam, Netherlands) · 2023Article
- Trace Analysis of Emerging Virus: An Ultrasensitive ECL-Scan Imaging System for Viral Infectious Disease.ACS omega · 2022Article
- Contemporary exploitation of natural products for arthropod-borne pathogen transmission-blocking interventions.Parasites & vectors · 2022Review
- Armigeres subalbatus is a potential vector for Zika virus but not dengue virus.Infectious diseases of poverty · 2022Article
- Widespread interspecific phylogenetic tree incongruence between mosquito-borne and insect-specific flaviviruses at hotspots originally identified in Zika virus.Virus evolution · 2022Article
Corrections and comments
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18 authors.
Funding
Abstract
Zika virus (ZIKV) is a mosquito-borne flavivirus that predominantly circulates between humans and Aedes mosquitoes. Clinical studies have shown that Zika viruria in patients persists for an extended period, and results in infectious virions being excreted. Here, we demonstrate that Aedes mosquitoes are permissive to ZIKV infection when breeding in urine or sewage containing low concentrations of ZIKV. Mosquito larvae and pupae, including from field Aedes aegypti can acquire ZIKV from contaminated aquatic systems, resulting in ZIKV infection of adult females. Adult mosquitoes can transmit infectious virions to susceptible type I/II interferon receptor-deficient (ifnagr-/-) C57BL/6 (AG6) mice. Furthermore, ZIKV viruria from infected AG6 mice can causes mosquito infection during the aquatic life stages. Our studies suggest that infectious urine could be a natural ZIKV source, which is potentially transmissible to mosquitoes when breeding in an aquatic environment.
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