ArticleNature communications2019
Hippocampal CA1 replay becomes less prominent but more rigid without inputs from medial entorhinal cortex.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 59 citations in OpenAlex.
- Anti-NMDAR encephalitis impairs intrinsic hippocampal dynamics through neuronal hypercoupling, hub dominance, and aberrant ensembles.Molecular psychiatry · 2026Article
- Hippocampal Long Axis Differentiation in Memory and Seizure Networks.Epilepsy currents · 2026Article
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- Hippocampal ripple diversity organizes neuronal reactivation dynamics in the offline brain.Neuron · 2025Article
- Incremental self-organization of spatio-temporal spike pattern detection.Scientific reports · 2025Article
- Competition and cooperation of assembly sequences in recurrent neural networks.PLoS computational biology · 2025Article
- Distinct roles of dentate gyrus and medial entorhinal cortex inputs for phase precession and temporal correlations in the hippocampal CA3 area.Nature communications · 2025Article
- Sleep microstructure organizes memory replay.Nature · 2025Article
- Electroanatomy of hippocampal activity patterns: theta, gamma waves, sharp wave-ripples, and dentate spikes.Frontiers in behavioral neuroscience · 2025Article
- Article
- Remapping revisited: how the hippocampus represents different spaces.Nature reviews. Neuroscience · 2024Review
- The association of GNB5 with Alzheimer disease revealed by genomic analysis restricted to variants impacting gene function.American journal of human genetics · 2024Article
- Article
- Associative and predictive hippocampal codes support memory-guided behaviors.Science (New York, N.Y.) · 2023Article
- A theory of hippocampal theta correlations accounting for extrinsic and intrinsic sequences.eLife · 2023Article
- Hippocampal sharp-wave ripples and their spike assembly content are regulated by the medial entorhinal cortex.Current biology : CB · 2023Article
- Offline memory replay in recurrent neuronal networks emerges from constraints on online dynamics.The Journal of physiology · 2023Article
- Article
- The two tales of hippocampal sharp-wave ripple content: The rigid and the plastic.Progress in neurobiology · 2023Review
- Low Rate Hippocampal Delay Period Activity Encodes Behavioral Experience.bioRxiv : the preprint server for biology · 2023Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
The hippocampus is an essential brain area for learning and memory. However, the network mechanisms underlying memory storage, consolidation and retrieval remain incompletely understood. Place cell sequences during theta oscillations are thought to be replayed during non-theta states to support consolidation and route planning. In animals with medial entorhinal cortex (MEC) lesions, the temporal organization of theta-related hippocampal activity is disrupted, which allows us to test whether replay is also compromised. Two different analyses-comparison of co-activation patterns between running and rest epochs and analysis of the recurrence of place cell sequences-reveal that the enhancement of replay by behavior is reduced in MEC-lesioned versus control rats. In contrast, the degree of intrinsic network structure prior and subsequent to behavior remains unaffected by MEC lesions. The MEC-dependent temporal coordination during theta states therefore appears to facilitate behavior-related plasticity, but does not disrupt pre-existing functional connectivity.
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