ArticleProceedings of the National Academy of Sciences of the United States of America2019
Transcriptomic atlas of mushroom development reveals conserved genes behind complex multicellularity in fungi.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.
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81 citing papers in PubMed, 152 citations in OpenAlex.
- Basidiomycete fruiting body morphology correlates with the convergent loss of photolyase-related proteins.iScience · 2026Article
- Identification of Candidate Genes Associated with the Pileus-Deficient Phenotype inJournal of fungi (Basel, Switzerland) · 2026Article
- Transcriptomic and Physiological Profiling Reveals Metabolic Determinants and Key Regulatory Hubs of Fruiting Body Degeneration inJournal of fungi (Basel, Switzerland) · 2026Article
- Functional Annotation Workflow for Fungal Transcriptomes.Journal of fungi (Basel, Switzerland) · 2026Article
- Cryometamorphosis expression patterns of fruiting body development in the mushroom-forming fungusIMA fungus · 2026Article
- Emerging roles of protein modifications in sexual reproduction and pathogenesis of filamentous fungi.Frontiers in microbiology · 2026Review
- A genomic perspective on fungal diversity and evolution.Nature reviews. Microbiology · 2025Review
- Transcriptome Analysis and Its Application in Screening Genes Related to the Growth and Development ofJournal of fungi (Basel, Switzerland) · 2025Article
- Morphogenesis, starvation, and light responses in a mushroom-forming fungus revealed by long-read sequencing and extensive expression profiling.Cell genomics · 2025Article
- Whole-Genome Characterization ofJournal of fungi (Basel, Switzerland) · 2025Article
- Article
- Transcriptome analysis of different developmental stages ofCurrent research in microbial sciences · 2025Article
- Orthrus: a Pumilio-family gene involved in fruiting body and dark stipe development inFrontiers in fungal biology · 2025Article
- Advancements in genetic studies of mushrooms: a comprehensive review.World journal of microbiology & biotechnology · 2024Review
- Snowball: a novel gene family required for developmental patterning of fruiting bodies of mushroom-forming fungi (Agaricomycetes).mSystems · 2024Article
- Unravelling the Transcriptional Response ofInternational journal of molecular sciences · 2024Article
- Adaptive advantages of restorative RNA editing in fungi for resolving survival-reproduction trade-offs.Science advances · 2024Article
- Flammutoxin, a Degradation Product of Transepithelial Electrical Resistance-Decreasing Protein, Induces Reactive Oxygen Species and Apoptosis in HepG2 Cells.Foods (Basel, Switzerland) · 2023Article
- Integration of Metabolomes and Transcriptomes Provides Insights into Morphogenesis and Maturation inJournal of fungi (Basel, Switzerland) · 2023Article
- Altered Expression of Two Small Secreted Proteins (International journal of molecular sciences · 2023Article
21 more citing papers are in PubMed but not listed here.
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Authors and funding
24 authors at 7 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The evolution of complex multicellularity has been one of the major transitions in the history of life. In contrast to simple multicellular aggregates of cells, it has evolved only in a handful of lineages, including animals, embryophytes, red and brown algae, and fungi. Despite being a key step toward the evolution of complex organisms, the evolutionary origins and the genetic underpinnings of complex multicellularity are incompletely known. The development of fungal fruiting bodies from a hyphal thallus represents a transition from simple to complex multicellularity that is inducible under laboratory conditions. We constructed a reference atlas of mushroom formation based on developmental transcriptome data of six species and comparisons of >200 whole genomes, to elucidate the core genetic program of complex multicellularity and fruiting body development in mushroom-forming fungi (Agaricomycetes). Nearly 300 conserved gene families and >70 functional groups contained developmentally regulated genes from five to six species, covering functions related to fungal cell wall remodeling, targeted protein degradation, signal transduction, adhesion, and small secreted proteins (including effector-like orphan genes). Several of these families, including F-box proteins, expansin-like proteins, protein kinases, and transcription factors, showed expansions in Agaricomycetes, many of which convergently expanded in multicellular plants and/or animals too, reflecting convergent solutions to genetic hurdles imposed by complex multicellularity among independently evolved lineages. This study provides an entry point to studying mushroom development and complex multicellularity in one of the largest clades of complex eukaryotic organisms.
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