Evidence map›Paper›PMID 30902853›Full record

ArticleApplied and environmental microbiology2019

Novel Antifungal Compound Z-705 Specifically Inhibits Protein Kinase C of Filamentous Fungi.

Asumi Sugahara, Akira Yoshimi, Fumio Shoji, Tomonori Fujioka, Kiyoshi Kawai, Hideaki Umeyama, Katsuichiro Komatsu, Masaru Enomoto, Shigefumi Kuwahara, Daisuke Hagiwara and 5 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Applied and environmental microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Asumi Sugahara *Laboratory of Applied Microbiology, Department of Microbial Biotechnology, Graduate School of Agricultural Sciences, Tohoku University, Sendai, Miyagi, Japan.
Akira Yoshimi *ABE-project, New Industry Creation Hatchery Center, Tohoku University, Sendai, Miyagi, Japan.
Fumio ShojiLaboratory of Applied Microbiology, Department of Microbial Biotechnology, Graduate School of Agricultural Sciences, Tohoku University, Sendai, Miyagi, Japan.
Tomonori FujiokaKumiai Chemical Industry Co., Ltd., Tokyo, Japan.
Kiyoshi KawaiKumiai Chemical Industry Co., Ltd., Tokyo, Japan.
Hideaki UmeyamaSchool of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
Katsuichiro KomatsuIn-Silico Sciences, Inc., Tokyo, Japan.
Masaru EnomotoLaboratory of Applied Bioorganic Chemistry, Graduate School of Agricultural Sciences, Tohoku University, Sendai, Miyagi, Japan.
Shigefumi KuwaharaLaboratory of Applied Bioorganic Chemistry, Graduate School of Agricultural Sciences, Tohoku University, Sendai, Miyagi, Japan.
Daisuke HagiwaraABE-project, New Industry Creation Hatchery Center, Tohoku University, Sendai, Miyagi, Japan.
Takuya KatayamaDepartment of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
Hiroyuki HoriuchiDepartment of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
Ken MiyazawaLaboratory of Applied Microbiology, Department of Microbial Biotechnology, Graduate School of Agricultural Sciences, Tohoku University, Sendai, Miyagi, Japan.
Mayumi NakayamaLaboratory of Applied Microbiology, Department of Microbial Biotechnology, Graduate School of Agricultural Sciences, Tohoku University, Sendai, Miyagi, Japan.
Keietsu AbeLaboratory of Applied Microbiology, Department of Microbial Biotechnology, Graduate School of Agricultural Sciences, Tohoku University, Sendai, Miyagi, Japan kabe@niche.tohoku.ac.jp.
Tohoku University · JPThe University of Tokyo · JPKitasato University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The cell wall integrity signaling (CWIS) pathway is involved in fungal cell wall biogenesis. This pathway is composed of sensor proteins, protein kinase C (PKC), and the mitogen-activated protein kinase (MAPK) pathway, and it controls the transcription of many cell wall-related genes. PKC plays a pivotal role in this pathway; deficiencies in PkcA in the model filamentous fungus

Indexed as

Antifungal AgentsAspergillus nidulansFungal ProteinsMagnaportheMicroorganisms, Genetically-ModifiedProtein Kinase CSaccharomyces cerevisiaeSignal TransductionAntifungal AgentsFungal ProteinsProtein Kinase Ccell wall integrity signalingfilamentous fungiin silico screeningPKC inhibitorprotein kinase C

Identifiers

PMID30902853
PMCPMC6498157
OpenAlexW2923687617

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.